摘要
以1-氰乙基-2-甲基咪唑(2MZCN)为原料催化氢化制备1-氨丙基-2-甲基咪唑,考察了反应过程中合成工艺参数对产物的影响,确定较为适宜的工艺条件为:温度100℃,压力5 MPa,转速624 r/min,时间4 h,溶剂是氨的饱和乙醇溶液(与原料质量比是2∶1),雷尼镍为催化剂(占原料质量的18.9%),氢氧化钾为助催化剂,原料的转化率可达99.7%,产率可达94.2%。采用红外光谱(FTIR)和核磁共振氢谱(1HNMR)及气质联用(GC-MS)对产物进行了表征。
1-Ammonia propyl-2-methyl imidazole was synthesized by catalytic hydrogenation of 1- eyanoacetate-2-methylimidazole （2MZCN）, and the parameters of the synthetic process were investigated systematically in order to ascertain the appropriate synthetic conditions. The conversion of 2MZCN and the yield of 1-amino-propyl-2-methyl imidazole reached 99.7% and 94. 2% respectively after reaction for 4 h under the conditions of reaction temperature of 100 ℃ ,pressure of 5 MPa, speed of 624 r/min, and the solvent of saturated ethanol solution of ammonia（ the mass ratio of the solution to the raw material is 2：1 ）, Raney nickel was the catalytic agent and potassium hydroxide acted as catalyst promoter（ accounting for a mass fraction of 18.9% of the raw material）. The product was analysed by infrared spectroscopy（FTIR） and proton nuclear magnetic resonance spectroscopy（1HNMR） and gas chromatography-mass spectrometer（ GC-MS）.
出处
《精细化工》
EI
CAS
CSCD
北大核心
2013年第11期1298-1302,共5页
Fine Chemicals
