摘要
目的探讨雷公藤多甙、激素联合参芪地黄汤治疗难治性肾病综合征临床疗效。方法选择我院2010年1月～2013年1月70例难治性肾病综合征患者的资料；根据其治疗方法分为观察组及对照组，各35例，两组均采用雷公藤多甙及甲泼尼龙片治疗；观察组患者加用参芪地黄汤，连续治疗6个月，对两组患者的治疗效果进行评价。结果观察组治疗后与治疗前24h尿蛋白定量、血浆白蛋白、血肌酐比较，差异有统计学意义（t值与P值分别为7．4、6．5、5．2；0．018、0、023、0．031）；对照组治疗后与治疗前24h尿蛋白定量、血浆白蛋白、血肌酐比较，差异有统计学意义（t值与P值分别为7．7、6．1、5．9；0．014、0、025、0：033）；观察组患者治疗后24h尿蛋白定量、血浆白蛋白、血肌酐等指标改善优于对照组，比较差异有统计学意义（，值与户值分别为，6．4、7．3、5．5；o．023、0、015、0．038）；观察组、对照组患者治疗前中医症候积分分别为24．3±5．6、24.8±4；8，治疗后分别为12．2±3．6、18．5±5．4，观察组患者降低明显，与对照组患者比较差异有统计学意义（P〈0．05）。结论参苠地黄汤治疗难治性肾病综合征，对患者蛋白尿、血肌酐等指标均有明显改善作用，提高患者生活质量，值得在临床推广。
Objective To study the clinical curative effect of sbenqidihuang decoction combined with hormone and glucosidorum tripterygll totorum in the treatment of refractory nephrotic syndrome. Methods Seventy patients with refractory nephrotic syndrome in our hospital during January 2010 to January 2013 were selected, and were divided into the observation group and the control group according to its therapeutic methods, each group had 35 patients. The two groups were treated with glucosidorum tripterygll totorum and methylprednisolone tablets for 6 months,and the observation group was added shenqidihuang decoction for 6 months,the clinical curative effect of two groups were evaluated. Results The differences were statistically significant on the 24h urine protein quantitative, plasma albumin, serum creatinine in the observation group between before and after treatment（the t value was 7.4,6.5,5.2 respectively,while the corresponding p value was 0.018,0.023,0.031 respectively）; The differences were statistically significant on the 24h urine protein quantitative, plasma albumin, serum creatinine in the control group between before and after treatment（the t value was 7.7,6.1,5.9 respectlvely,while the corresponding p value was 0.014,0.025,0.033 respectively）; The improvement of 24h urine protein quantitative, plasma albumin,serum creatinine after treatment in the observation group were better than those in the control group,the differences were statistically significant between two groups（the t value was 6.4,7.3,5.5 respectively, while the corresponding p value was 0.023,0.015,0.038 respectively）; The TCM symptom score before treatment in the observation group and the control group was 24.3 ：t： 5.6,24.8 ± 4.8 respectively, while after treatment was 12.2 ± 3.6,18.5± 5.4 respectively,the TCM symptom score in the observation group reduced significantly compared with the control group,the difference was statistically significant（P 〈 0.05）. Conclusion Shenqi dihuang decoction in the treatment of refractory nephrotie syndrome has significant improvement on proteinuria, serum ereatinine and other indicators of patients,can improve patients ＇ quality of life,and is worthy of clinical popularization.
出处
《中国医药科学》
2013年第20期79-81,共3页
China Medicine And Pharmacy
关键词
雷公藤多甙
甲泼尼龙
参芪地黄汤
肾病综合征
临床疗效
Glucosidorum tripterygll totorum
Methylprednisolone
Shenqidihuang decoction
Nephroticsyndrome
Clinical curative effect
