摘要
探讨一新的毒力因子相关基因群 cag致病岛中cagⅠ部分在中国人群感染幽门螺杆菌 (Hp)中的检出率及其与临床疾病的关系。采用PCR方法检测了 10 7例临床分离培养的Hp菌株 ,扩增cagⅠ中的 170bp片段。结果 :cagⅠ的阳性检出率为 86 .9% ,在慢性胃炎、消化性溃疡、胃癌等疾病间的检出无显著差异 (P >0 .0 5 )。并且与胃粘膜组织的淋巴细胞、浆细胞、嗜中性粒细胞等炎症细胞的浸润程度无关 (P >0 .0 5 )。结论 :cagⅠ在中国人群感染Hp中的检出率很高 ,在慢性胃炎、消化性溃疡、胃癌等疾病中均有相当高的检出率 ,但其检出率在疾病间比较无统计学差异。
To investigate the distrbution of cag Ⅰin Helicobacter pylori(Hp) isolated from Chinese patients, and its relationship to gastroduodenal diseases. Fragment in cag Ⅰ was amplified by polymerase chain reaction(PCR) in 107 Hp strains from Chinese patients. Results The amplicom to cag Ⅰ was positive in 93 strains, of which 57 strains came from patients with chronic gastritis, 31 strains from peptic ulcer, and 5 strains from gastric carcinoma.Conclusion Existance of cag Ⅰ of Hp strains was popular in the Chinese population, but no data had proven the relation ship between the existence of cag 1and occurrence of Hp related diseases and inflammatory infiltration in gastric mucosa.
出处
《解放军医学杂志》
CAS
CSCD
北大核心
2000年第6期398-400,共3页
Medical Journal of Chinese People's Liberation Army
基金
国家自然科学基金!(编号 396 70 6 48)
欧共体委员会科学基金!(IC18CT95 0 0 2 4)资助课题
