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地塞米松与尿激酶联合应用注入胸腔治疗大鼠结核性胸膜炎的实验研究 被引量：5

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摘要 目的探讨地塞米松与尿激酶联合应用注入大鼠胸腔对结核性胸膜炎疗效的影响。方法将60只SD大鼠根据体质量按随机数字表法分为A、B、C组3组,每组20只。建立结核性胸膜炎后,A组大鼠右侧胸腔内注入地塞米松+尿激酶,B组注入尿激酶,C组注入等量的生理盐水。在24、72 h及5、7 d观察并记录各组大鼠排液量、肺功能、胸膜厚度和黏连情况。结果 24、72 h胸腔积液量A组高于B组、B组高于C组(均P<0.05),7 d后胸腔积液量A组少于B组和C组(P均<0.05)。24 h后胸膜厚度A组低于B组(P<0.01),B组低于C组(P<0.01)。肺功能指标方面,PEF A组优于B组(P<0.05),B组优于C组(P<0.01),FEV0.3 A组优于B组(P<0.05),B组优于C组(P<0.01)。5、7 d时胸腔粘连评分A组优于B组,B组优于C组(均P<0.05)。结论大鼠胸腔内联合注入尿激酶与地塞米松的效果优于单独注射等剂量的尿激酶。
作者 王小路 梅敏 钱小军
机构地区 江西省胸科医院内三科
出处 《实用临床医学（江西）》 CAS 2013年第8期12-13,25,共3页 Practical Clinical Medicine
关键词 结核性胸膜炎 地塞米松 尿激酶 联合 胸腔注射 动物 实验 大鼠
分类号 R-322 [医药卫生]
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实用临床医学（江西）
2013年 第8期

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