摘要
目的探讨染色体核型分析在全血细胞减少症病因诊断中的作用。方法采用骨髓直接法和24 h培养法,并用R显带技术,对229例全血细胞减少症患者的染色体核型进行分析。结果 229例全血细胞减少症患者中,再生障碍性贫血和巨幼细胞性贫血染色体无异常,77例染色体异常的全血细胞减少症病因均为恶性疾病。结论染色体核型分析有助于全血细胞减少症病因的诊断,尤其在骨髓形态学原始细胞不高和病态造血不明显的全血细胞减少症的病因诊断中提供重要的依据。
Objective To explore the effect of karyotype analysis in the etiological diagnosis of pancytopenia. Methods Karyotype analysis was performed in 229 patients with pancytopenia using the direct method, 24-hour culture method and C-banding technique. Results In 229 cases of pancytopenia patients, aplastie anemia and megaloblastic anemia were without chromo- somal abnormalities, 77 cases of pancytopenia with chromosomal abnormalities were malignant diseases. Conclusion The karyotype analysis can help to diagnose the cause of pancytopenia, especially for the etiological diagnosis of pancytopenia without enough bone marrow blasts and obvious morbid hematopoiesis.
出处
《哈尔滨医科大学学报》
CAS
北大核心
2013年第5期457-458,461,共3页
Journal of Harbin Medical University
