摘要
目的骨髓涂片和骨髓活检同步检查分析全血细胞减少的病因,以及临床血液参数指标分析。方法收集2011～2012年120例全血细胞减少的患者资料,分析评估临床表现和血液参数;骨髓样本采用骨髓抽吸、活检同步法取材,骨髓涂片和活检染色后,行骨髓形态学观察。结果 120例全血细胞减少患者中,最常见的临床症状是乏力、面色苍白和发热,其次是脾肿大。全血细胞减少最常见的病因是巨幼细胞性贫血(49.2%),其次是骨髓发育异常综合症(23.3%)和再生障碍性贫血(10.0%)。通过骨髓涂片和骨髓活检同步检查能提高全血细胞减少的确诊率。结论在全血细胞减少的诊断中,骨髓涂片和骨髓活检同步检查对了解疾病的过程和确定病因有诊断价值,同时对临床进一步检查和治疗提供重要的帮助。
Objective To study the clinical presentations in pancytopenia due to various causes;and to evaluate hematological parameters by the examinations of bone marrow smear and trephine biopsy. Methods We study simultaneously bone nmrrow smear and trephine biopsy in 120 patients with pancytopenia, evaluate clinically, along with hematological parameters and bone marrow morphology. Results Among 120 cases studied, most of the patients presented with generalized weakness and fever. The commonest physical finding was pallor, followed by splenomegaly and hepatomegaly. The commonest cause for pancytopenia was megaloblastic anemia（49.2% ） ,followed by MDS（23.3% ） and aplastic anemia（ 10.0% ）. It can elevate the diagnosis rate of the causes of pancytopenia by the use of bone marrow smear and trephine biopsy. Conclusion The present study concluded that detailed primary hematological investigations along with bone marrow aspiration in pancytopenic patients were helpful for under- standing disease process and to diagnose or to rule out the causes of pancytopenia. These were also helpful in planning further in- vestigations and management.
出处
《中华全科医学》
2012年第11期1705-1705,1730,共2页
Chinese Journal of General Practice
