摘要
目的:探讨骨髓增生异常综合征(MDS)的细胞遗传学异常及其演变与MDS的亚型和转归的关系。方法:采用骨髓细胞直接法和(或)短期培养法按常规制备染色体,采用R显带技术进行核型分析。结果:8例MDS检出染色体异常核型,占40%,主要异常有5q-,+8,-7,t/del(3)(q21),-18;MDS-RAEB和RAEBT(63.7%)比MDS-RA(11.1%)异常核型检出率高(P<0.05),且多为复杂异常;核型异常者进展为白血病的危险性明显高于核型正常者。结论:MDS的核型分析对其明确诊断,分型和预后评价有重要的参考价值。
Objective: To explore the relationship of cytogenetic abnormalities and its evolution with the subtypes of myelodysplastic syndrome (MDS) and the prognosis of MDS patients. Methods: Metaphase chromosomes were prepared using direct method and (or) short-term culture method. Karyotyping was performed using R-banding technique. Results: Abnormal chromosomes were detected in 8 (40%) cases, including del(5q), tirsomy 8, t/del(3)(q21), and monosomy 18. The incidence of cytogenetic abnormalities was higher in patients with high risk group (RAEB and RAEBt) than in that of low risk group (RA) (63.7% vs 11.1%, P<0.05). Complex karyotype abnormalities were predominantly observed in high risk group. The risk of leukemic transformation was higher in cases with abnormal karyotypes than with normal karyotypes. Conclusion: Karyotype analysis was very useful for the diagnosis, classification, and prognosis evaluation in MDS.
出处
《江苏大学学报（医学版）》
CAS
2005年第2期149-151,共3页
Journal of Jiangsu University：Medicine Edition
