摘要
目的 观察结直肠癌病人血清Ⅳ型胶原 (ColⅣ )及层粘连蛋白 (LN)的含量变化并探讨其意义。方法 选择结直肠癌病人 51例作观察组 (其中 4 1例行根治术 ) ,32例非肿瘤手术病人作对照组 ,采用放射免疫法测定ColⅣ和LN。结果 观察组ColⅣ和LN的含量明显高于对照组(P <0 0 1) ,其中DukesB期及C期明显高于A期 (P <0 0 1) ,根治术后ColⅣ及LN较术前下降 (P<0 0 5)。结论 ColⅣ及LN与结直肠癌的浸润转移相关 ,检测其含量有助于判断病情和预后。
Objective To observe the change of serum collagen type Ⅳ(ColⅣ)and lominin(LN)levels in patients with colon-rectal carcinoma and to study its significance.Methods 51 cases with colon-rectal carcinoma were selected as Treating Group(among which 41 cases received radical operation).32 cases with non-tumor operation were taken as Control Group.ColⅣ and LN levels were determined with radioimmunoassay.Results ColⅣ and LN levels of Treating Group were markedly higher than those of Control Group(both P <0.01),and those of Dukes phase B and phase C were markedly higher than those of phase A(both P <0.01).Levels of ColⅣ and LN after radical operation were lower than those before aperation (both P <0.05).Conclusion ColⅣ and LN are correlated with infiltration and metastasis of colon-rectal carcinoma.Delermination of their levels helps evaluation of patients condition and prognosis.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
2000年第6期478-478,共1页
Cancer Research on Prevention and Treatment
