摘要
DMRT(double-sex and mab-3 relatated transcription factor)基因家族是一个与性别决定有关的基因家族,它编码的转录因子具有一个保守的DM(double-sex and male aberrant-3 relative domain)结构域,靠特殊的锌指结构连接DNA。目前研究表明,DMRT基因家族主要参与胚胎的性别分化、性腺的发育、配子的形成,并且参与神经发育等其他功能。该文主要从DMRT基因的结构、功能和作用机理三个方面对DMRT基因家族的研究进展进行了综述。
The DMRT gene family is a gene family related to sexual determination. Transcription factors encoded by DMRT genes have a conserved DM-domain linking to DNA by special zinc finger structures. The present studies of DMRT genes show that they mainly participate in sexual differentiation of embryo, developing of gonads and formation of gametes, and take part in other functions such as neurodevelopment. This paper reviews the advances in the DMRT gene family research, and expounds its structure, function and mechanism of action.
出处
《中国细胞生物学学报》
CAS
CSCD
北大核心
2013年第11期1660-1665,共6页
Chinese Journal of Cell Biology
基金
国家高技术研究发展计划("863")(批准号:2008AA092604)
山东省自然基金(批准号:ZR2010CM030)资助的课题~~
