摘要
目的探讨慢性阻塞性肺疾病(COPD)内分泌激素水平变化及其与缺氧程度的相关性。方法选取50例慢性阻塞性肺疾病急性发作期(AECOPD)患者,以动脉氧分压(PaO2)水平分为重度缺氧组、中度缺氧组、轻度缺氧组,并在急性发作期和缓解期分别测定血清总三碘甲状腺原氨酸(TT3)、总四碘甲状腺原氨酸(TT4)、促甲状腺激素(TSH);血清皮质醇(FC)、醛固酮(ALD)、促肾上腺皮质激素(ACTH)水平。同时选取40例健康体检者作为对照组进行比较。结果①COPD患者与对照组激素水平相比,不论急性发作期还是缓解期,FC、TT3下降,ALD、ACTH升高,均有显著差异(P<0.05),而TT4、TSH虽有下降,但无显著性差异(P>0.05);②COPD缓解期患者与急性发作期患者比较,FC、TT3、ALD、ACTH等的变化亦具有差异性显著(P<0.05);③COPD患者缺氧程度越重,相关激素水平的变化越明显,伴随缺氧纠正,激素水平渐趋恢复。结论 COPD患者,尤其是急性发作期,内分泌激素水平存在显著异常,缺氧越严重,相关激素水平变化越大;但伴随缺氧纠正,激素水平渐趋恢复。
Objective： To investigate the chronic obstructive pulmonary disease （COPD） hormone levels and the degree of correlation with hypoxia. Methods ： Fifty cases of chronic obstructive pulmonary disease with acute exacerbation （ AECOPD） were divided into severe hypoxia, moderate hypoxia group and mild hypoxia group according to the arterial oxygen （PaO2 ） levels. In the acute phase, serum total three triiodothyronine （TT3 ）, total four triiodothyronine （ TT4 ）, thyroid stimulating hormone （TSH）, serum cortisol （ FC）, aldosterone （ALD）, and adrenocorticotropie hormone （ACTH） levels were detected. Forty healthy volunteers were also selected as the control group for comparison. Results： The increases in FC, TT3 decline, ALD and ACTH were significantly different （ P 〈 0.05 ）, in the COPD patients with hormone levels in comparison to healthy subjects, while Tr4, TSH decreased, but there was no significant difference （ P 〉 0.05 ） ; the difference was significant in patients of remission phase in comparison with those of acute exacerbation（ P 〈 0.05 ） ; while hypoxia was more severe, related changes in hormone levels was more obvious. Conclusion： COPD patients, especially those of acute exacerbation at endocrine hormone levels, are significantly abnormal, and the more severe hypoxia is, the greater changes in hormone levels are; but with the correct hypoxia, hormone levels can be gradually restored.
出处
《泰山医学院学报》
CAS
2013年第8期572-575,共4页
Journal of Taishan Medical College
关键词
慢性阻塞性肺疾病
内分泌激素
缺氧
chronic obstructive pulmonary disease
endocrine hormones
hypoxia
