血清总胆汁酸、转氨酶联合测定对妊娠期肝内胆汁淤积症的临床意义被引量：13

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摘要目的探讨血清总胆汁酸(TBA)、转氨酶水平的测定对妊娠期肝内胆汁淤积症(ICP)的诊断及胎儿预后的关系,为临床ICP的诊断和新生儿的预后提供理论依据。方法回顾性分析2009年1月至2012年12月在我院住院分娩的108例ICP患者的血清TBA和血清转氨酶的水平值对ICP的诊断价值及两者的不同水平值与新生儿宫内窘迫及羊水粪污染的关系。结果 TBA在ICP孕妇中的增高幅度可达正常的2～3倍,大于血清转氨酶的升高幅度;随着TBA或血清转氨酶水平值的升高,羊水粪污染及胎儿宫内窘迫率均有增高,但多数差异无统计学意义(P>0.05);当血清TBA、转氨酶同时升高时,羊水粪污染及胎儿宫内窘迫发生率均明显增高,差异均有统计学意义(P<0.05),且胎儿宫内窘迫发生率差异更为显著(P<0.01)。结论血清TBA对于ICP的诊断优于ALT、AST,而血清TBA联合转氨酶的水平测定更能反映ICP对胎儿的影响程度。

作者吴粤湘

机构地区湖南省娄底市妇幼保健院

出处《中国医药指南》 2013年第29期102-103,共2页 Guide of China Medicine

关键词 TBA 血清转氨酶 ICP 胎儿宫内窘迫羊水粪污染

分类号 R714.25 [医药卫生—妇产科学]

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1王如英.妊娠期肝内胆汁淤积症孕妇肝功能指标与围生儿预后的关系[J].中国妇幼保健,2008,23(27):3818-3819. 被引量：7
2刘春芳.妊娠肝内胆汁瘀积的发病机制研究进展[J].国外医学（临床生物化学与检验学分册）,2002,23(6):367-369. 被引量：7
3丁依玲,唐玲玲.妊娠肝内胆汁淤积症患者胎盘合体滋养细胞超微结构的观察与脐静脉血总胆酸水平的测定[J].中华妇产科杂志,2005,40(7):453-456. 被引量：28

二级参考文献21

1Maria AS, Dora B, Monica G, et al. Beneficial effect of ursodeoxycholic and on alterations induced by cholestasis of pregnancy in bile acid transport across the human placenta. J Hepatol, 1998, 28:829-883.
2Ceryak S, Bouscarel B, Malavolti M, et al. Extrahepatic deposition and cytotoxicity of lithocholic acid: studies in two hamster models of hepatic failure and in cultured human fibroblasts. Hepatology,1998,27:546-556.
3Leslie KK, Reznikov L, Simon FR, et al. Estrogens in intrahepatic cholestasis of pregnancy. Obstet Gnyecol,2000, 95:372-376.
4Pasanen M, Helin-Martikainen HL, Pelkonen O. Intrahepatic cholestasis of pregnancy impairs the activities of human placental Xenobiotic and steroid metabolizing enzymes in vitro. Placenta,1997,18:37-41.
5溶酶体金传荫译.Roger TD[M].北京:科学出版社出版,1983.20-23.
6Philip JH, Gerry MM. Bile acid stress in the mother and baby unit.Europ J Gastroenterol Hepatol,2003,15:317-321.
7Rocio R,Macias RI, Pascual MJ, et al. Effect of maternal cholestasis on bile acid transfer across the rat placenta-maternal liver tandem. Hepatology,2000,31:975-983.
8Alsulyman OM, Ouzounian JG, Ames - Castro M et al. lntrahepatic cholestasis of pregnancy: perinatal outcome associated with expectant management. Am J Obstet Gynecol, 1996, 175 (41): 957
9TypstrupN,SteigBA,JuinJA ,etal.Recurrentfamilialin trahepaticcholestasisinthefaeroeislands.Phenotypichetero geneitybutgenetichomogeneity[].Hepatology.1999
10Reyes H.Intrahepatic Cholestasis: a puzzling disorder of pregnancy[].Journal of Gastroenterology.1997