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妊娠肝内胆汁瘀积的发病机制研究进展 被引量：7

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摘要 妊娠肝内胆汁瘀积症 (ICP)对孕妇可造成瘙痒、黄疸、脂肪及脂溶性维生素吸收障碍 ,对围产儿可致早产、胎儿宫内窘迫、围产期病死率增高。但其发病机制不明。近来的研究表明该病与性激素、胆汁酸、遗传、环境等多种因素有关。本文对有关因素及发病机制的研究进展进行综述。
作者 刘春芳
机构地区 重庆医科大学检验系
出处 《国外医学（临床生物化学与检验学分册）》 2002年第6期367-369,共3页 Foreign Medical Sciences(section of Clinical Biochemistry and Laboratory Medicine
关键词 发病机制 研究进展 妊娠肝内胆汁瘀积症 胆汁酸 性激素
分类号 R714.255 [医药卫生—妇产科学]
  • 相关文献

参考文献10

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同被引文献42

  • 1王晓东,姚强,周凡.2011年中国《妊娠期肝内胆汁淤积症诊疗指南(第1版)》解读[J].中国医学前沿杂志（电子版）,2013,5(7):41-43. 被引量：11
  • 2漆洪波,胡丽娜.瘦素与妊娠的关系[J].中华围产医学杂志,2005,8(2):137-139. 被引量：8
  • 3丁依玲,唐玲玲.妊娠肝内胆汁淤积症患者胎盘合体滋养细胞超微结构的观察与脐静脉血总胆酸水平的测定[J].中华妇产科杂志,2005,40(7):453-456. 被引量：28
  • 4[4]Sjovall J,Reyes H.Bile acids and progesterone metabolites in intrahepatic cholestasis of pregnancy[J].Ann Med,2000,32(2):94-106.
  • 5[5]Pandak WM,Schwarz C,Hylemon PB,et al.Effects of CYP7A1 overexpression on cholesterol and bile acid homeostasis[J].Am J Physiol Gastrointest Liver Physiol,2001,281(4):878-889.
  • 6[6]Mazzella G,Nicola R,Francesco A,et al.Ursodexycholic acid administration in patients with cholestasis of pregnancy:effects on primary bile acid in babies and mothers[J].Hepatology,2001,33(3):504-508.
  • 7Pandak WM,Schwarz C,Hylemon PB,et al.Effects of CYP7A1 overexpression on Cholesterol and bile acid homeostasis[J].Am J Physiol Gastrointest Liver Physiol,2001,281(4):G878-889.
  • 8刘元娇 曹来英.新编妇产科疾病诊疗学[M].北京:人民卫生出版社,2002.393-401.
  • 9Reyes H, Sjovall J. Bile acids and progesterone metabolites in intrahepatic cholestasis of pregnancy. Ann Med , 2000,32: 94-106.
  • 10Chiang JY. Bile acid regulation of hepatic physiology. E. Bile acids and nuclear receptors. Am J Physiol Gastrointest . Liver Physiol ,2003 , 284 : G349-356.

引证文献7

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国外医学（临床生物化学与检验学分册）
2002年 第6期

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