摘要
目的探讨老年慢性阻塞性肺病(COPD)患者白介素-6(IL-6)及肿瘤坏死因子-α(TNFα)的水平变化及与临床分期、通气功能障碍程度的关系。方法选取94例COPD患者并分为急性加重期组(n=48)和稳定期组(n=46),另选取同期健康体检者36例设为对照组,比较各组的IL-6、TNF-α水平。根据FEV1%预计值,急性加重期组和稳定期组又分为轻、中、重三组,比较各组患者的IL-6、TNF-α水平。结果 COPD组IL-6、TNF-α水平高于对照组(P<0.05),急性加重期组高于稳定期组(P<0.05);急性加重期组和稳定期组的IL-6、TNF-α水平随着通气功能障碍程度加重而逐步增加。结论 IL-6、TNF-α参与了COPD的慢性炎症反应,并且与临床分期、通气功能障碍程度有一定相关性。
Objective To investigate the levels of IL-6 and TNF-α, and their relationships with clinical stage, ventilation dysfunction in elderly patients with chronic obstructive pulmonary disease （COPD）. Methods Ninety-four patients （48 AECOPD cases, 46 remission cases） and 36 healthy subjects were enrolled as study group and control group. According to FEV1% predicted, cases of COPD （AECOPD and remission cases） were respectively divided into mild/medium/severe case group. Serum levels of IL-6, and TNF-α of cases in each group were analyzed. Results Levels of IL-6 and TNF-α were higher in COPD cases than in controls （P〈0.05）. Level s of IL-6 and TNF -α gradually increased with the severity of airway dysfunction either in the cases of AECOPD or re- mission group. Conclusion IL-6 and TNF-α are involved in the chronic inflammatory reaction of COPD, having a certain correlation with the clinical stage and ventilation dysfunction.
出处
《实用临床医药杂志》
CAS
2013年第19期4-6,共3页
Journal of Clinical Medicine in Practice
