摘要
目的:探讨肿瘤坏死因子-α(TNF-α)及白介素-8(IL-8)在慢性阻塞性肺疾病(COPD)发病机制中的作用。方法:收集28例COPD急性加重期患者,25例COPD缓解期患者和30例健康者的静脉血,离心后取血清,采用酶联免疫法(ELISA)测定其中TNF-α及IL-8水平,同时对COPD急性期患者常规测定动脉血PaO2、PaCO2。结果:COPD急性加重期患者血清TNF-α及IL-8水平明显高于缓解期及健康对照组,缓解期明显高于对照组(P<0.05);COPD急性加重期血中TNF-α及IL-8含量与PaO2成负相关,与PaCO2呈正相关。结论:TNF-α及IL-8参与了COPD气道炎性反应,TNF-α及IL-8检测对COPD诊断和预后判断具有积极作用。
Objective：To evaluate the implication of TNF-α and IL-8 in chronic obstructive pulmonary disease（COPD）.Methods：Serum levels of TNF-α and IL-8 were determined by ELISA in 28 patients with acutely exacerbated COPD,25 patients with stableCOPD and 30 healthy subjects served as contro1.PO2,PCO2 were assayed also,and the relationship among these parameters wasstatistically analyzed.Results：The serum TNF-α and IL-8 levels in acute exacerbated COPD were obviously higher than those in stableCOPD patients as well as the healthy controls;the stable COPD patients were obviously higher than that of the healthy controls.Furthermore,The serum TNF-α and IL-8 levels of acutely exacerbated COPD patients were negatively correlated with the PO2 andpositively correlated with PCO2.Conclusion：Serum TNF-α and IL-8 may participate in the airway inflammatory process of COPD.
出处
《现代医药卫生》
2010年第14期2106-2107,共2页
Journal of Modern Medicine & Health
