摘要
目的评价慢性阻塞性肺疾病(COPD)患者急性加重期血清白细胞介素8(IL-8)的变化特点及其与肺功能的相关性,探讨IL-8在COPD中的临床意义。方法分别测定63例COPD急性加重期患者治疗前后血清IL-8水平及一秒钟用力呼气容积/用力肺活量(FEV1/FVC),并进行相关性分析。结果COPD急性加重期患者治疗前后IL-8水平对比分析具有显著差异(P<0.001)。同时,血清IL-8与FEV1/FVC呈负相关。结论IL-8参与了COPD的气道炎症,对判断COPD的急性加重、治疗效果及呼吸功能具有重要的临床意义。
Objective To evaluate clinic significance of interleukin-8 （IL-8） in patients with acute exacerbation of chronic obstructive pulmonary disease （COPD）, and to study the correlation between IL-8 and lung function. Methods The serum level of IL-8 were measured in 63 patients with acute exacerbation of COPD before and after treatment. There were examinations in all patients on forced expiratory volume in one second of forced expiratory volume （FEV1/FVC）, and their correlation with IL-8 and lung function. Results IL-8 concentration in serum of acute exacerbation of COPD after treatment was significantly higher than that before treatment （P〈0. 001）. The level of IL-8 was negatively correlated with FEV1/FVC. Conclusion IL-8 is involved in airway inflammation of COPD, and may have important clinic significance in assessing acute exacerbation, the effect of treatment and pulmonary function of COPD.
出处
《西部医学》
2007年第2期190-191,共2页
Medical Journal of West China
关键词
慢性阻塞性肺疾病
白细胞介素8
肺功能
Chronic obstructive pulmonary disease
Interleukin-8
Pulmonary function
