摘要
目的了解乙肝疫苗接种后保护效果,评价相关年龄段儿童抵御乙肝病毒能力,为完善乙肝防控策略提供依据。方法采取整群随机抽样方法采集涪城区城乡15岁及以下仅接受了3针乙肝疫苗接种儿童血清,采用双抗原夹心时间分辨免疫荧光分析法(IFMA法)对乙肝表面抗体(Anti—HBs)定量检测,分析乙肝抗体保护率及变化趋势。结果本次共调查了符合条件的1 503名儿童,抗-HBs阳性率为59.9%;1岁组抗体阳性率最高为95.3%,1～3岁期间乙肝抗-HBs滴度和阳性率下降最快,到6岁组抗体阳性率下降到最低37.5%,而后逐渐缓慢有所上升,但都低于1～3岁组;乙肝抗-HBs滴度与性别、城乡差异无关。结论 3～6岁儿童人群虽全程接种完3针乙肝疫苗,但依然有较高的乙肝病毒感染风险;此阶段儿童应根据抗-HBs检测结果,及时加强免疫。
This study designed to explore the protective effect of hepatitis B vaccine, evaluate the anti- hepatitis B virus ability of define ages of children, and to provide a basis for improvement of hepatitis B prevention and control strategies. We used cluster random sampling method to collect the 15 years and younger children＇s serum who only accept three vaccination of hepatitis B vaccine in Fucheng urban and rural areas. IFMA method was employed for quantitative detection of hepatitis B surface antibody. Total of 1503 eligible children demonstrated an average anti-HBs-positive-rate of 59.9%. One-year-old children group showed the positive rate of 95.3%, while 1-3 ear-old children group showed the most quickly decrease of anti-HBs titer, and 6-year-old group down to a minimum of 37.5%. And then with age increase, the anti-HBs-positive-rate gradually increased, but lower than that of 1-3 year-old group. We also found anti-HBs titer was independent with gender and region. In conclusion, the group of 3-6 years old children still has a higher risk of hepatitis B virus infection, although they accepted three vaccination of hepatitis B vaccine. Children in these ages should be boostered timely according to the result of the detection of anti-HBs.
出处
《免疫学杂志》
CAS
CSCD
北大核心
2013年第11期1010-1012,共3页
Immunological Journal
基金
国家"十一五"重大科技专项(2009ZX10004-905)
关键词
乙肝疫苗
免疫效果
加强免疫
Hepatitis B vaccine
Immune effect
Booster immunization
