曲美他嗪治疗慢性非缺血性心脏病心衰疗效观察被引量：5

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摘要目的观察曲美他嗪(万爽力)治疗慢性非缺血性心脏病心力衰竭的临床疗效。方法入选62例慢性非缺血性心脏病心力衰竭患者,常规标准治疗稳定1个月后,将患者随机分为万爽力治疗组(32例)和常规治疗对照组(30例),分别于用药前及用药后1个月、6个月记录NYHA心功能分级、6min步行距离及超声心动图左室射血分数(LVEF)、左室舒张末期容积(LVEDV)变化情况,观察用药前后心功能变化。结果治疗组治疗1个月、6个月NYHA心功能分级、6min步行距离、LVEF、LVEDV等心功能各项指标明显改善,与对照组相比差异有统计学意义(P<0.05)。结论万爽力有进一步改善非缺血性心脏病心力衰竭患者心功能的作用。

作者赵虹潘永源李晓辉高成梅

机构地区首都医科大学宣武医院

出处《中西医结合心脑血管病杂志》 2013年第10期1183-1184,共2页 Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

关键词非缺血性心力衰竭曲美他嗪超声心动图 6 min步行距离

分类号 R541.6 [医药卫生—心血管疾病]

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参考文献9

1Morser M, Frishman W. Effects of carvedilol, a vasodilator - beta - blocker,in patients with congestive heart failure due to ischemic heart disease[J]. Circulation,1995,92(2) : 212 - 218.
2Mario M, Werner W. Efficacy and tolerability of trimetazidine in stable angina : A meta - analysis of randomized, double - blind, con trolled trails[J]. Coronary Artery Disease,200,114(2): 171 - 178.
3黄小春.曲美他嗪对缺血性心力衰竭患者心率变异性的影响[J].中西医结合心脑血管病杂志,2012,10(9):1033-1034. 被引量：10
4Killalea SM,Krum H. Systematic review of the efficacy and safety of perhexiline in the treatment of ischemic heart disease[J]. Am J Cardio Drugs,2001,1(3) :193 - 204.
5Cristina V, Mauricio W, Barbara S, et al. Trimetazidine improves left ventricular function and quality of life in elderly patients with coronary artery disease[J]. Eur Heart J,2004,25:1814 - 1821.
6Gahrieieragasso F,Gianluca P, Francesco D, et al. Effects of meta- bolic modulation by trimetazidine on left ventricular function and phosphocreatine/adenosinetripb- osphare- ratio in patinents with heart failure[J].Eur Heart J, 2006,27:942 - 948.
7Neubauer S. The failing heart - an engine out of fuel[J]. N Engl ] Med,2007,356(11) :1140 - 1151.
8Fragasso G, Rosano G, Back SH, et al. Effect of partial fatty acid oxidation inhibition with trimetazidine on mortality arid morbidity in heart failure: Results from an international muhicentre retro- spective cohort study[J].Int J Cardiol, 2013,163 (3): 320 - 325.
9黄昶荃,董碧蓉.曲美他嗪治疗慢性充血性心力衰竭疗效的系统评价[J].中国循证医学杂志,2007,7(1):37-44. 被引量：10

二级参考文献20

1刘雪保,周达新,葛均波.曲美他嗪佐治扩张型心肌病心功能的作用[J].江西医药,2005,40(1):50-51. 被引量：5
2江美芝.曲美他嗪对慢性阻塞性肺疾病心衰患者心功能影响的观察[J].实用临床医学（江西）,2005,6(5):11-12. 被引量：3
3付慎文,金烈,徐育红,潘轶斌,许洁伟,杜永远.曲美他嗪对扩张型心肌病心功能衰竭的疗效观察[J].中国临床医学,2005,12(3):533-534. 被引量：6
4Boogers MJ , Veltman CE, Bax JJ. Cardiac autonomic nervous sys -tern in heart failure: Imaging technique and clinical implicaiions[J]. Curr Cardiol Rev,2011,7(1) : 35 - 42.
5KisKi T. Heart failure as an autonomic nervous system dysfunction[J]. J Cardiol,2012,59(2) :117 - 122.
6Kleiger RE.Miller JP,Bigger JT, et al. Decreased heart rate vari-ability and its association with increased mortality after acute myo-cardial infarction[j]. Am J Cardiol,1987,59(4) :256 - 262.
7Sookan T, McKune AJ. Heart rate variability in physically activeindividuals:Reliability and gender characteristics[J]. Cardiovasc JAfr,2012,23(2):67 - 72.
8Huikuri HV, Stein PK. Clinical application of heart rate variabilityafter acute myocardial infarction[j]. Front Physiol,2012,3 :41.
9Buccelletti E, Gilardi E, Scaini E,et al. Heart rate variability andmyocardial infarction . Systematic literature review and metanalysis[J]. Eur Rev Med Pharmacol Sci,2009,13(4) :299 - 307.
10Gunes Y, Guntekin U, Tuncer M, et al. Improved left and rightventricular functions with trimetazidine in patients with heart fail-ure: A tissue Doppler study[J]. Heart Vessels, 2009 , 24(4) : 277 -282.