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曲美他嗪对冠状动脉粥样硬化性心脏病合并慢性心力衰竭患者心功能指标及血清NT—proBNP水平的影响 被引量:8

Influence of trimetazidine on cardiac function indicators and serum level of NT-proBNP in patients with coronary atherosclerotic heart disease complicating chronic heart failure
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摘要 目的、分析曲美他嗪对冠状动脉粥样硬化性心脏病(冠心病)合并慢性心力衰竭患者心功能指标及血清氨基末端脑钠肽前体(NT—proBNP)水平的影响。方法抽取2015年1月至2016年2月本院冠心病合并心力衰竭患者74例,依据不同治疗方案分为研究组(n=37)和对照组(n=37)。对照组采用常规治疗措施,研究组在常规治疗基础上加用曲美他嗪,两组均持续治疗6个月。对比治疗前后两组心功能相关指标水平、血液流变学相关指标、6min步行试验(6MWT)及血清NT—proBNP水平变化情况,并统计两组不良反应发生率。结果治疗前两组LVEF、LVEDV、LVESV、LVESD、LVEDD、6MWT及NT—proBNP水平对比差异均无统计学意义(均P〉0.05),经治疗,研究组优于对照组,差异均有统计学意义(均P〈0.05);治疗前两组纤维蛋白原、血红细胞比容、血浆黏度、全血粘度切变率水平对比差异均无统计学意义(均P〉0.05),经治疗,研究组纤维蛋白原、血浆黏度、全血粘度切变率均优于对照组,差异均有统计学意义(均P〈0.05);研究组不良反应发生率(13.51%)与对照组(16.21%)对比,差异无统计学意义(P〉0.05)。结论采用曲美他嗪治疗冠状动脉粥样硬化性心脏病合并慢性心力衰竭效果显著,可有效改善患者心功能及血液流变学水平,降低血清NT—proBNP水平,且不良反应发生率较低,安全性较高,值得推广。
作者 高桂丽 Gao Guili(First Department of Internal Medicine, Second People's Hospital of Xin 'an County, Luoyang 471800, China)
出处 《国际医药卫生导报》 2017年第5期701-704,共4页 International Medicine and Health Guidance News
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