摘要
目的:通过观察不同剂量天宁饮对偏头痛患者TNF-α及血液流变学的影响,了解从风痰瘀阻论治偏头痛的作用机制。方法:将126例偏头痛患者随机分为低剂量组、高剂量组和对照组3组,分别予口服天宁饮(高剂量、低剂量)、西比灵胶囊。结果:(1)治疗前后治疗组TNF-α值、血液流变学各项指标及差值与对照组相比,P<0.01、P<0.05;但治疗组组间比较,除了全血低切还原黏度和红细胞聚集指数有差异外其余各项指标均无明显差异P>0.05。(2)3组患者在治疗期间均未见不良反应。结论:天宁饮可通过降低血黏度和TNF-α的水平达到缓解头痛的目的;低剂量组与高剂量组总体疗效相仿。
Objective：Through the observation of the intervention of different dosages of Tianning Decoction on hemorheology and TNF - α level in patients with migraine to learn the mechanism of wind, phlegm and blood stasis on treating migraine. Meth- ods.126 patients of migraine were randomly divided into normal dose group,high dose group and control group. The normal dose group and high dose group were treated with Tianning Decoction, and the control group were treated with flunarizine hydrochloride capsules. Results ： （ 1 ） TNF - α and hemorheology after treatment, the difference between the treatment groups and the control group was significant, P 〈 0.01 ,P 〈 O. 05. While the comparison between the treatment groups had no difference except for blood viscosity at the low shear rate and indexes of erythrocyte aggregation, P 〉 0.05. （2） There were no obvious adverse reactions in the three groups during treatment. Conclusion ： Tianning Decoction can reduce plasma viscosity and the level of TNF - α to improve the symptoms of migraine. There were no significant differences between normal dose and high dose of Tianning Decoction in the total clinical effects.
出处
《辽宁中医杂志》
CAS
2013年第10期1969-1971,共3页
Liaoning Journal of Traditional Chinese Medicine
基金
江苏省中医药局科技项目资助(LZ11174)
