摘要
目的 探讨一氧化氮 (NO)、超氧化物歧化酶 (SOD)分别及联合使用对大鼠实验性蛛网膜下腔出血(SAH)后脑血管痉挛 (CVS)时脑血流 (CBF)的作用。方法 将 30只大鼠随机分成 5组 (每组 6只 )。A组 :假手术+盐水 ;B组 :SAH+盐水 ;C组 :SAH+ SOD;D组 :SAH + NOC12 ;E组 :SAH+ SOD、NOC12。模型制成 48h后 ,通过 L aser- Doppler血流仪观察各种药物持续静脉注射 1h内 CBF的变化。结果 A、B两组 CBF无改变 ,C、D、E各组 CBF均明显增加 ,但 E组增加程度高于 C、D两组。结论 NO及 SOD分别能使 CVS时的 CBF增加 ,且两者联合使用效果优于单独使用。
Objectives To explore the effects of nitric oxide(NO) and superoxide dismutase(SOD) respectively and combinedly used on cerebral blood flow(CBF) in cerebral vasospasm of experimental subarachnoid hemorrhage(SAH) in rats. Methods 30 rats were divided into five groups(n=6). A:psudosurgery+Saline;B:SAH+Saline;C:psudosurgery+NOC12;D:SAH+NOC12;E:SAH+NOC12+SOD. 48 hours after model was made, changes of CBF during venous injection of various drugs were observed continuously with Laser-Doppler for 1 hour. Results CBF showed no change in group A and B,but marked increase in group C、D and E,but the increase in group E were more significant than that in group C and D. Conclusions Both NO and SOD increase CBF of CVS, and combined use of them show better effects than single.
出处
《中风与神经疾病杂志》
CSCD
北大核心
2000年第5期286-287,共2页
Journal of Apoplexy and Nervous Diseases
关键词
蛛网膜下腔出血
脑血管痉挛
一氧化氮
SOD
Subarachnoid hemorrhage
Cerebral vasospasm
Nitric oxide
Superoxide dismutase
Cerebral blood flow
