摘要
本文采用猫二次枕大池注血法复制了蛛网膜下腔出血(SAH)性脑血管痉挛(CVS)的模型,并以猫椎基动脉造影的方法检测了其脑血管痉挛的发生频度和强度。33只家猫的实验结果表明:一次注血后半小时 CVS 的发生率为98%,重度为74%,但2小时后发生率即降为64%,重度者降至9%;二次注血后第一天 CVS 的发生率又升至87%,重度为67%,至二次注血后的第5天发生率仍达87%,重度为73%。可见二次注血可提高 CVS 的发生频度与强度,并符合临床规律,有助于对慢性期 CVS 的研究。并对急、慢性 CVS 的关系进行了讨论。
An animal model of cerebral vasospasm (CVS)following subarachnoid hemorrhage (SAH) was pro-duced in adult cats by injection autologous arterialblood twice (3ml/each) into cisterna magna.Incidenceand intensity CVS was studied by vertebro-basilarartery angiography.Thirty three cats of either sexwere randomized into three groups:control,blood in-jection once and blood injection twice.After generalanesthesia,vertbro-basilar artery angiography weredone by selecting catheterization of right subclavianartery,then 3ml cerebrol spinll fluid was drawn fromcisterna magna,and 3ml fresh auto]ogous arterialblood was injected into cisterna magna.The same pro-ceedure was repeated 48 hours after first injection.Angiogram were taken at 30min,3 hours,3 (5,7,14&21) days respectively,all experimental cat waskilled hy perfusion fixation solution after final angio-graphy.The results showed that twice blood injectioncan increase incidence and intensity of CVS,It con-forms the reality clinical rules and may help study ofchronic CVS.the relation between acute & chronicCVS is discussed also.
出处
《中华神经外科杂志》
CSCD
北大核心
1993年第4期210-212,共3页
Chinese Journal of Neurosurgery
