摘要
目的 探讨丹参素 (DS- 182 )、原儿茶酸 (PCAD)、原儿茶醛 (PCADH) 3种丹参有效水溶性成分和三碘甲状腺氨酸(T3)对心肌挫伤的治疗作用 .方法 白色家兔 30只 ,分为 5组 ,建立心脏撞击心肌挫伤模型 ,分别以 T3,DS- 182 ,PCADH,PCAD治疗 ,观察左心室收缩压峰值 (L VSP)、血清中甲状腺激素和 CPK含量、血液流变学指标、受挫伤心肌中 NO和MDA含量的变化 .结果 家兔心脏撞击伤后 ,血清中 FT3下降 ,FT4浓度和 CPK值升高 ,L VSP明显下降 ;T3组 L VSP显著高于对照组 ,且基本纠正 FT3浓度的改变 ;DS- 182使心肌组织 MDA的含量显著降低 ,NO的含量显著升高 ,并改善血液流变学指标 ,提高 L VSP;PCAD作用较弱 ;PCADH基本没有治疗作用 .结论 T3能明显提高心肌挫伤后心肌收缩功能 ,其作用可能与扭转血清中 FT3下降有关 .DS- 182降低心肌挫伤后继发性自由基损害 ,维持 NO的合成 ,改善心肌组织的血液供应 ,提高心肌收缩力 ,是丹参注射液中起治疗作用的主要成分 .PCAD作用较 DS- 182弱 。
AIM To study the effects of T_3 and the water-soluble components of salvia miltiorrhiza on contused myocardium. METHODS After establishing the models of myocardial contusion, thirty rabbits were divided into five groups: A control group and groups treated with T_3,DS-182,PCADH and PCAD respectively. The level of CPK,FT_3 and FT_4 in the plasma, the content of NO and MDA in the contused myocardium were measured, and LVSP was observed. RESULTS After contusion, the level of LVSP and FT_3 was significantly lower in the control group, that of CPK and FT_4 was obviously higher. Compared with control group, LVSP and FT_3 were improved in T_3 group. Compared with control group, in DS-182 group, the content of MDA reduced, while the content of NO increased, and LVSP was improved. In addition, in PCAD group, there displayed a similar but weaker effect, while PCADH group showed no therapeutic effects. CONCLUSION T_3 can improve LVSP and correct the decreased FT_3 in plasma after myocardial contusion. Water-soluble components of salvia mitiorrhiza may exert therapeutic effects on the secondary myocardial damage by improving hemorrheological situations, reducing OFR damage, and maintaining the level of NO.DS-182 is the most effective component for the treatment of myocardial contusion in salvia mitiorrhiza.
出处
《第四军医大学学报》
2000年第12期1513-1515,共3页
Journal of the Fourth Military Medical University
关键词
丹参
三碘甲状腺氨酸
心肌挫伤
心功能不全
components of salvia miltiorrhiza
triiodothyronine
myocardial contusion
