摘要
目的:探讨杏丁注射液对心肌挫伤的治疗作用,为临床救治心肌挫伤提供实验依据.方法:利用BIM-II型生物撞击机制备兔严重心肌挫伤模型;并用杏丁注射液进行治疗作为对照.分别于撞击前5min,撞击后5,30min,2,4,8,24h采颈总动脉血检测血栓素A2(TXA2)、前列环素(PGI2)的含量;于伤后24h摘取心脏作光镜检查,随机取2只兔心作电镜检查,观察心肌组织形态学改变.结果:血浆PGI2浓度在伤后早期(伤后4h)明显下降,而血浆TXA2浓度则明显升高.形态学检查心肌组织损伤较重.用杏丁注射液治疗后血浆PGI2浓度降低和TXA2浓度升高都较轻,心肌组织损伤也明显减轻.结论:杏丁注射液对心肌挫伤有治疗作用,其机制可能与杏丁注射液升高血浆PGI2浓度和降低TXA2浓度有关.
AIM： To explore the role of Xingding injection （XDI）, an injection made of traditional Chinese medicinal herbs, in the treatment of myocardial contusion in rabbits. METHODS： Thirty rabbits were randomly divided into three groups： control group with false-impact （control group, n = 10）, severe myocardial contusion group （MC group, n = 10） and XDI treatment group （XDI group, n = 10）. The models of rabbit with severe myocardial contusion were made by BIM-II Horizontal Bioimpact Machine. At 5 min before impact and 5 min, 30 min, 2, 4, 8 and 24 h after impact, blood samples were taken from common carotid artery of rabbits in each group to measure the concentrations of plasma thromboxane A2 （ TXA2 ） and prostacyclin （ PGI2 ） by radioimmunoprecipitation. At the end of the experiment, the heart of one rabbit from each group was harvested to observe the microstructural changes and 2 hearts were randomly taken from each group to observe ultra-structural changes. RESULTS： The concentrations of plasma PGI2 had a distinct falling-off while the contents of plasma TXA2 were significantly higher in the early period of severe myocardial contusion （ at 4 h after myocardial contusion ）. The morphological injuries of myocardial tissues were severe. With XDI, the reduction of the concentrations of plasma PGI2 and the increase of the contents of plasma TXA2 were significantly relieved. The morphological injuries of myocardial tissues were obviously lessened. CONCLUSION： Xingding injection can improve the reduction of the concentrations of plasma PGI2 and the increase of the contents of plasma TXA2 in the early period of severe myocardial contusion, which may concentrate to its therapeutic effect on severe myocardial contusion.
出处
《第四军医大学学报》
CAS
北大核心
2005年第16期1484-1486,共3页
Journal of the Fourth Military Medical University
基金
贵州省"十五"社会发展攻关课题[黔科合农社字(2001)1132号]
