摘要
目的探讨基质金属蛋白酶9(Martix Metalloproteinase 9,MMP-9)和PTEN在胶质瘤中的表达状况,并探讨它们之间的相关性及临床意义。方法应用组织芯片技术和免疫组织化学EnVision法检测67例胶质瘤、8例正常脑组织中MMP-9、PETN的表达。结果 MMP-9蛋白在胶质瘤组织和正常脑组织中的表达差异没有统计学意义(P>0.05),随着胶质瘤恶性程度的增加,MMP-9蛋白表达增加(P<0.05)。PTEN蛋白在脑胶质瘤组织和正常脑组织中的表达差异有统计学意义(P<0.05)。随着胶质瘤恶性程度的增加,PTEN蛋白表达降低(P<0.05)。MMP-9与PTEN在各级胶质瘤组织中的表达无相关性(P>0.05)。结论胶质瘤MMP-9与PTEN的表达没有相关性。MMP-9高表达与PTEN表达下降提示胶质瘤的侵袭性增高。
Objective To explore the expression and clinical significance of MMP-9 and PTEN protein in gliomas. Methods The expressions of MMP-9 and PTEN protein in 67 gliomas,8 normal brain specimens were detected by tis- sue microarray technique and immunohistochemistry method. Results There was not significant difference in the posi- tive rates of MMP-9 between normal brain tissues and gliomas（P〈0.05）. The positive reaction rate of MMP-9 was in- creased with the increase of tumor malignancy（P〈0. 05）. There was a singnficant difference in the positive rates of PTEN between normal brain tissues and gliomas（P〈0.05）. The expression of PTEN was decreased with the increase of malignancy（P〈0.05）. There was not a correlation between MMP-9 and PTEN in gliomas（P〉0.05）. Conclusion There is not a correlation between MMP-9 and PTEN;High expression of MMP-9 and decreased expression of PTEN prompts the increasing invasion of gliomas.
出处
《中国实验诊断学》
2013年第10期1811-1814,共4页
Chinese Journal of Laboratory Diagnosis
