摘要
目的探讨腰大池引流加庆大霉素冲洗治疗鲍氏不动杆菌颅内感染的临床疗效,为其临床治疗提供参考依据。方法收集2009年1月-2012年12月30例颅脑创伤术后颅内感染患者资料,所有患者脑脊液检查均为鲍氏不动杆菌感染,采用随机数字法平均分为两组,A组患者给予腰大池引流加庆大霉素冲洗治疗措施;B组患者给予应用头胞哌酮/舒巴坦治疗,观察两组患者的疗效。结果治疗总有效率A组为86.7%、B组为66.7%,A组疗效明显优于B组,差异有统计学意义(P<0.05);患者住院时间A组(11.6±1.2)d、B组(23.3±1.5)d,差异有统计学意义(P<0.05);治疗后3dA组患者体温(37.3±0.5)℃、脑脊液白细胞(35.1±7.5)×106/L,B组分别为(38.2±0.6)℃、(36.1±8.6)×106/L,治疗后7dA组患者体温(37.1±0.4)℃、脑脊液白细胞(9.2±1.4)×106/L;B组分别为(37.6±0.5)℃、(16.6±3.3)×106/L,两组患者与治疗前相比差异有统计学意义(P<0.05);其中A组患者体温及CSF白细胞下降更明显,与B组相比差异有统计学意义(P<0.05)。结论腰大池引流加庆大霉素冲洗治疗鲍氏不动杆菌颅内感染有较好的临床疗效,可更好地降低患者的体温,改善患者的症状,值得临床推广应用。
OBJECTIVE To discuss the clinical curative effect of lumbar cistern drainage and gentamicin flushing in treatment of intraeranial infections with Acinetobacter baumannii and provide reference for the clinical treatment. METHODS Data of 30 eraniocerebral trauma patients with postoperative intracranial infections during Jan. 2009 to Dec. 2012 were collected. All patients were detected with A. baurnannii infections through the cerebrospinal fluid examination. Patients were equally divided into two groups by the random digital method. Patients in group A were treated with lumbar cistern drainage with gentamicin flushing, while patients in group B were administrated with cefoperazone/sulbactam the curative effect was observed. RESULTS Patients in group A had better effects than group B, the total effective rates were 86.7% and 66.7~, respectively, the difference was significant （P~ 0.05）. And the hospital time [or patients in group A （11.6＋_1.2 d） was less ~han ~hat o{ group ~ （23.3＋_1.5 d）, with significant differences （P〈0.05）. At 3 d after treatment, the body temperature and the CSF white blood cell count for group A and group B were 37.3--＋0.5 ~C and （35.1~7.5） 〉〈 106/L, 38.2：J=0.6 ~C and （36.1＋_8.6） 〉〈 106/L, respectively. At 7 d after treatment, the body temperature and the CSF white blood cell count for group A and group B were 37.1 ~ 0.4 ~C and （9.2 J= 1.4） X 106/L, 37.6 J= 0.5 ~C and （16.6-＋- 3.3） 〉〈 106/L, respectively. There were significant differences between the two groups compared with before treatment. Group A had more obvious decreases in the body temperature and the CSF white blood cell count compared with group B significantly （P〈O. 05）. CONCLUSION Lumbar cistern drainage with gentamicin flushing can achieve good clinical curative effect on treatment of intracranial infection with A. baumannii, which can reduce the body temperature.It is worthy of clinical application.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2013年第19期4776-4778,共3页
Chinese Journal of Nosocomiology
基金
国家自然科学基金(81071049)
关键词
腰大池引流
庆大霉素
鲍氏不动杆菌
颅内感染
Lumbar cistern drainage
Gentamicin
Acinetobacter baumannii
Intracranial infection
