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白细胞介素1α mRNA在结直肠癌中的表达及意义 被引量：1

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摘要 白细胞介素（IL）-1α是一种多功能细胞因子，主要由活化的巨噬细胞和淋巴细胞合成并分泌，不仅参与炎症反应，而且在肿瘤发生发展中发挥重要作用。体外实验显示，IL-1α在结直肠癌细胞株中明显高表达，可促进肿瘤血管形成，并且与结直肠癌细胞肝转移有关。临床实验显示，结直肠癌患者血浆中IL-1α蛋白表达明显升高。迄今为止，尚未见结直肠癌中IL-1αmRNA的表达变化研究报道。本研究采用实时荧光定量PCR检测IL-1α mRNA在结直肠癌及癌旁组织中的表达，并探讨其临床意义。
作者 田维军 张鑫 赵金伟 侯波
机构地区 吉林省人民医院急诊外科
出处 《中国老年学杂志》 CAS CSCD 北大核心 2013年第18期4579-4580,共2页 Chinese Journal of Gerontology
关键词 结直肠癌 实时荧光定量PCR 白细胞介素1Α
分类号 R735.3 [医药卫生—肿瘤]
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参考文献8

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二级参考文献27

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中国老年学杂志
2013年 第18期

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