摘要
目的分析60岁以上老年人结直肠癌的临床流行病学特征。方法从广西医科大学第一附属医院病案信息科数据库导出结直肠肛门外科2003年1月—2010年12月住院病例资料,其中有病理诊断的结直肠癌初次住院患者2 810例,根据年龄分为老年组(≥60岁)、中年组(36～59岁)和青年组(≤35岁),比较三组的病例资料。结果老年人结直肠癌发病中位年龄为69岁,男女比为1.97∶1;肿瘤以直肠、乙状结肠和右半结肠为主要部位;术前心血管疾病、肺部炎症性疾病、Ⅱ型糖尿病和结直肠腺瘤合并率为13.46%、4.15%、7.36%、7.20%,明显高于中、青年组(P<0.05);术前癌性肠梗阻合并率6.89%,高于中年组(P<0.05);同时性肝转移率为11.58%,不同年龄组相比差异无统计学意义(P>0.05);管状腺癌为主要组织学类型,占86.85%,高度恶性组织学类型包括黏液腺癌、印戒细胞癌和未分化癌,占4.46%,明显低于中、青年组(P<0.05)。结论广西地区老年人群结直肠癌患者中,男性约为女性两倍,女性患者比例未出现明显增加;临床以术前基础并发症多、比较容易发生癌性肠梗阻、伴发结直肠腺瘤的比例较高为特点;病理以管状腺癌为主要组织学类型,高度恶性组织学类型较青壮年少,预后较好。
Objective To explore the clinical epidemiologic characteristics of the elderly patients with colo- rectal carcinoma （CRC）. Methods Analysis and summary was made for 2 81（1 CRC patients pathological- ly confirmed in the first affiliated hospital of Guangxi medical university. These patients were divided into the elderly group,mid-aged group and young group. Results The median age was 69 years in the elderly patients and the ratio of male to female was 1. 97：1. Rectum,sigmoid and right colon were the main tumor size. The concomitant ratios of cardiovascular diseases, pulmonary inflammatory diseases, type 2 diabetes and colorectal adenoma in the elderly group, apparently higher than mid aged group and young group, were 13.46% ,4. 15% ,7.36% ,7.20% ,respectively. The rate of the obstructive CRC in the elderly group and young group surpassed the one of in the mid aged group. The patients with synchronous liver metas- tasis accounted for 11.58% of total elderly patients,and the difference among three groups did not show a statistical significance（P〉 0.05）. The major histological type was tubular adenocarcinom （86. 85 %）. The highly malignant histological forms including mucinous carcinoma,signet ring cell cancer and undif- ferentiated carcinoma in the elderly group, was obviously lower than another two groups. Conclusion There are almost twice as many elderly male patients with CRC as elderly female ones in the Guangxi re gion,and the female percent did not increased evidently. The elderly patients with CRC had these features such as more concomitant preoperative basic diseases,occurred easily colorectal obstruction and with higher-rate color- ectal adenoma. The maior histological type in the elderly group was tubular adenocarcinoma,and the ratio of the highly malignant histological kinds was very lower, which indicated better prognosis.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
2013年第1期98-101,共4页
Cancer Research on Prevention and Treatment
基金
广西教育厅科研资助项目(201012MS039
201012MS041)
广西研究生教育创新计划资助项目(2011105981002D34)
关键词
老年人
结直肠癌
临床流行病学
Elderly patients
Colorectal carcinoma
Clinical epidemiology
