摘要
哺乳动物的精卵识别是通过精子表面糖蛋白和透明带 ( ZP)糖蛋白的特异性识别完成的 ,这两种糖蛋白结构互补。透明带糖蛋白有三种成分 ( ZP1 、ZP2 和 ZP3) ,其中 ZP3被认为是第一精子受体 ,能与顶体完整的精子结合 ,并诱发顶体反应 ( AR) ;ZP2 是第二精子受体 ,与发生 AR的精子结合 ;ZP1 只起连接ZP2 和 ZP3的作用。用 ZP糖蛋白免疫哺乳动物可造成卵巢功能早衰 ( POF) ,ZP-α.β作为异种载体蛋白诱发的抗体能阻断精卵结合 ,在精卵结合早期起抗生育的作用。
The sperm recognizing to eggs is completed in mammalian species by sperm head glycoproteins specific binding to a complementary glycoproteins located on the egg ZP.The egg ZP is constructed of three glycoproteins,termed ZP1,ZP2,ZP3.One of the ZP glycoproteins,ZP3,serves as the first receptor for spermatozoa,binds free swimming acrosome intact spermatozoa,and induce the acrosome reaction(AR).After ZP3 mediated acrosomal execytosis,the spermatozoa is postulated to bind to the secondary receptor,ZP2,ZP1,is the homodimeric filament crosslinker between ZP2 and ZP3.The ZP antigen immunization results in premature ovarian failure(POF).The antibody induced by ZP α、β serving as heterogeneous carrier proteins inhibits sperm binding to eggs.
出处
《动物医学进展》
CSCD
2000年第4期18-21,共4页
Progress In Veterinary Medicine
