摘要
透明带在哺乳动物的受精过程中发挥着重要作用，透明带化学成分及其生物活性的研究对于了解精卵识别、顶体反应的诱导等过程的分子机理具有重要意义．近１０年来的研究表明透明带主要由糖蛋白（ＺＰＧＰｓ）组成，是在细胞质内合成后转移至透明带的大多数动物的ＺＰＧＰｓ为４～５种，不同种类动物的ＺＰＧＰｓ的氨基酸序列存在高度同源性在受精过程中，ＺＰＧＰｓ具有精子受体和诱导顶体反应的双重作用，ＺＰＧＰｓ含有Ｎ－连接和Ｏ－连接寡聚糖，这些寡糖链是ＺＰＧＰｓ行使生物活性不可缺少的部分．
The mammalian zona pellucida plays a major role in the fertilization. The study of chemical substances in zona Pellucida and its bioactivities is of importance in studying the molecular mechanism of species-specific spermegg recognition and the induction of acrosome reaction. Studies in latest ten years show that zona pellucida mainly consists of glycoproteins which are synthesized inside oocyte and then tranferred to the outside of oocyte. Most animals have 4 or 5 kinds of ZPGPs, and of which proteins possess homologous. During the process of fertilization, ZPGPs are responsible for spermatozoa receptors and for the induction of acrosome reaction. ZPGPs contain N-linked and O-linkedoligosaccharides, which are essential to the bioactivities of ZPGPs.
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
1996年第3期233-236,共4页
Progress In Biochemistry and Biophysics
