摘要
目的观察黄葵对实验性肾病综合征的疗效,并探讨可能机制。方法实验大鼠复制成阿霉素(ADR)肾病(NS)模型,分为正常组、模型组、模型+强的松组、模型+黄葵组。于造模前、造模后2、4、6、8周分别测定24h尿蛋白定量;并于实验8周末分别测定血清总蛋白(TP)、白蛋白(Alb)、总胆固醇(TCH)、甘油三酯(TG)、低密度脂蛋白(LDL)、总超氧化物歧化酶(SOD)、丙二醛(MDA)。结果①治疗组各期尿蛋白量下降幅度均显著高于模型组(P< 0.05);黄葵组与强的松组相比,尿蛋白量下降幅度无差别。②实验8周末,治疗组TP、Alb升高幅度显著高于模型组(P<0.05);强的松组与模型组比较,TCH、TG、LDL的变化无差别;黄葵组TCH、TG、LDL下降水平均显著高于模型组、强的松组。③模型组SOD显著低于正常组(P<0.05);黄葵组总SOD升高水平显著高于模型组、强的松组。④24h尿蛋白量与血清总SOD呈直线负相关(r=-0.923,P<0.01);与血清TG呈直线正相关(r=0.945,P<0.01)。结论黄葵能显著改善肾病大鼠临床指标,其减轻尿蛋白的作用与清除氧自由基、降低血脂有关。
Objective To investigate the effect of Huang Kui in experimental nephrotic syndrome and its mechanism. Methods The experimental nephrotic syndrome was induced by adriamycin （ADR） on rats. The rats were randomly divided into four groups：normal control, nephrotic control, the groups treated with prednisone, Hung Kui. The urinary protein, serum TP, serum Alb, serum total SOD, serum MDA, serum TCH, serum TG were measured. Results The concentration of urinary protein in the groups treated with prednisone and Huang Kui was lower than that of nephritic control group; While the concentration of urinary protein in the prednisone＇ s group had not in different from Huang Kui＇ s. By the end of the experiment, the concentration of serum TP and Alb were higher in the groups treated by medicine than that of nephritic control. The concentration of serum total SOD was lower than that of normal control; While total SOD＇ s concentration of the group treated with Huang Kui was higher than that of nephritic control and predisone＇s control. The urinary protein was in a negative relation to serum total SOD; While a relation to serum TG. Conclusion Huang Kui can considerably improve clinic symptom of nephrotic rat. The increasing serum total SOD and decreasing lipid may be one of the mechanisms of decreasing urinary protein.
出处
《哈尔滨医科大学学报》
CAS
北大核心
2005年第4期352-354,357,共4页
Journal of Harbin Medical University
