摘要
目的 :观察三叉神经痛患者痛支与非痛支神经纤维中降钙素基因相关肽的含量变化 ,加深对三叉神经痛发病机理的认识。方法 :用免疫组织化学法观察 16例患者痛支与非痛支神经纤维组织中降钙素基因相关肽免疫反应阳性颗粒的差异。结果 :发现痛支神经组织中降钙素基因相关肽免疫反应阳性颗粒的数量、面积均显著多于、大于非痛支神经组织中的降钙素基因相关肽免疫反应阳性颗粒。结论 :我们认为 :三叉神经痛的痛支神经过度合成和释放降钙素基因相关肽可能促进了SP的释放 ,导致阵发性剧烈疼痛 ,并在局部形成神经源性炎症。
Objective: To observe calcitonin gene-related peptide in nerve fiber of the patients with trigeminal neuralgia and get a deeper understanding about its pathogenetic mechanism. Methods: CGRP-like immunoreactive positive granules of pain and painless branches in 16 cases were labeled using ABC immunohistochemistry methods, quantitative analysis was performed using HPIAS-1000 system. Results: The number and area of CGRP-like immunoreactive positive granules in the pain branches was much more and larger than that in the painless branches. Conclusions: Exccesive synthetise and release of calcitonin gene-related peptide in trigeminal nerve may promote release of SP, cause the intense paroxysmal pain and form a local neurogenic inflammation. [
出处
《口腔医学纵横》
CSCD
2000年第4期270-272,共3页
Journal of Comprehensive Stomatology
基金
全军医药卫生科研基金!资助题 (98M0 84)
关键词
三叉神经痛
降钙素基因相关肽
神经纤维
trigeminal neuralgia
calcitonin gene-related peptide
immunohistochemistry
