摘要
目的 :研究北京、沈阳两个地区汉族人群磺脲受体 (sulfonylureareceptor,SUR)基因第 2 4内含子 3t/c多态性与 2型糖尿病的相关性。方法 :采用配偶对作病例 对照研究。用聚合酶链反应 长度多态性的方法检测磺脲受体基因第 2 4内含子 3t/c多态性。结果 :SUR2 4内含子 3t/c多态性的基因型频率和等位基因频率在 2型糖尿病组和对照组间差异无显著性。结论 :在所筛查的北京、沈阳两地区人群中SUR基因 2 4内含子 3t/c多态性与
Obejective: To test the association of sulfonylurea receptor gene (SUR) polymorphism with type 2 diabetes mellitus. Methods: SUR gene intron 24 3 t/c polymorphism was invested by polymerase chain reaction and appropriate restriction enzyme (PCR RFLP) in 132 couples of type 2 diabetic cases normal controls. Results: The genotype frequencies and allele frequencies were not significantly different between the case and the control group. Conclusion: Sulfonylurea receptor gene intron 24 3t/c polymorphism is not associated with type 2 diabetes mellitus in Chinese population of Beijing and Shenyang.
出处
《北京医科大学学报》
CSCD
2000年第5期458-460,共3页
Journal of Peking University(Health Sciences)
关键词
Ⅱ型糖尿病
磺脲受体
基因多态性
遗传学
Sulfonylurea receptor
Gene
Diabetes mellitus, non insulin dependent/genet
Introns
