期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

磺脲受体1基因外显子16-3c/t多态性与格列齐特降血糖的关系 被引量：1

Relationship between the polymorphism of sylfonylurea receptor 1 extron 16-3c/t and decreased the blood glucose of gliclazide
暂未订购
导出
摘要 目的研究磺脲类药物受体1(SUR1)基因多态性与格列齐特降糖疗效的关系。方法用Taqman-PCR技术检测119例2型糖尿病患者SUR1基因型,分析基因型与血糖变化的关系。结果SUR1基因16外显子-3c/t位点的突变纯合子tt基因型患者,其基线空腹胰岛素水平高于野生纯合子cc基因型患者(P<0.05)。格列齐特治疗后,各基因型空腹血糖、餐后2h血糖、糖化血红蛋白、空腹胰岛素及胰岛素抵抗指数下降幅度均无显著性差异。结论16外显子-3c/t多态性与格列齐特降糖疗效无关。 Objective To investigate the relationshipe between the polymorphism of sulfonylurea receptor 1 （ SUR1 ） extron 16 - 3c/t and decreased the blood glucose of gliclazide. Methods SUR1 genotypes of 119 patients with type 2 diabetes were determined by Taqman - PCR. The association between the drug efficacy and genotypes was investigated. Results At baseline, the serum insulin of the group with tt genotype of SUR1 extron 16 - 3c/t was significantly higher than that of the group with cc genotype（ P 〈 0.05 ）. After treatment extron 16 - 3c/t gene polymorphism was no associated with decrease of FPG, 2hPG, HbA1 c, FINS and HOMA - IR （P 〉0.05）. Conclusion Extron 16 -3c/t gene polymorphism was no associated with the therapeutic efficacy of gliclazide, but related to insulin level.
作者 张慧娟 刘晓民 匡洪宇 孙宏 邢厚恂
机构地区 哈尔滨医科大学第一临床医院内分泌科 哈尔滨医科大学公共卫生学院 安徽省生物医学研究所
出处 《中国临床药理学杂志》 CAS CSCD 北大核心 2007年第5期369-371,共3页 The Chinese Journal of Clinical Pharmacology
基金 国家自然科学基金资助项目(30671802) 黑龙江省卫生厅医学科研课题资助项目(2006-014) 黑龙江省教育厅科研课题资助项目(11521122)
关键词 2型糖尿病 基因多态性 格列齐特 type 2 diabetes gene polymorphism gliclazide
分类号 R587.1 [医药卫生—内分泌] R977.15 [医药卫生—药品]
  • 相关文献

参考文献9

  • 1王劲松,周玲,成金罗,沈默宇.磺酰脲类受体基因多态性与2型糖尿病的相关性研究[J].遗传,2004,26(1):8-12. 被引量：9
  • 2Rissanen J,Markkanen A,Karkkainen P,et al.Sulfonylurea receptor 1gene variants are associated with gestational diabetes and type 2 diabetes but not with altered secretion of insulin[J].Diabetes Care,2000 ;23:70-73.
  • 3Inoue H,Ferrer J,Welling CM,et al.Sequence variants in the sulfonylurea receptor (SUR) gene are associated with NIDDM in Caucasians[J].Diabetes,1996 ;45:825-831.
  • 4纪立农,韩学尧,王虹,毛腾淑.磺脲类药物受体基因多态性与非胰岛素依赖型糖尿病的相关性[J].中华医学杂志,1998,78(10):774-775. 被引量：26
  • 5Huopio H,Otonkoski T,Vauhkonen I,et al.A new subtype of autosomal dominant diabetes attributable to a mutation in the gene for sulfonylurea receptor 1[J].Lancet,2003 ;361:301 -307.
  • 6Malecki MT.Genetics of type 2 diabetes mellitus[J].Diabetes Res Clin Pract,2005 ;68:10 -21.
  • 7Schulze MB,Hu FB.Primary prevention of diabetes:what can be done and how much can be prevented?[J].Annu Rev Public Health,2005;26:445-467.
  • 8Boileau P,Wolfrum C,Shih DQ,et al.Decreased glibenclamide uptake in hepatocytes of hepatocyte nuclear factor-1 alpha-deficient mice:a mechanism for hypersensitivity to sulfonylurea therapy in patients with maturity-onset diabetes of the young,type 3 (MODY3)[J].Diabetes,2002 ;51:343-348.
  • 9Nichols CG,Koster JC.Diabetes and insulin secretion:whither KATP?[J].Am J Physiol Endocrino Metab,2002 ;283:403 -412.

二级参考文献9

  • 1[1]Inagaki N,Gonoi T,Clement J P I,Namba N,Inazawa J,Gonzalez G,Aguilar B L,Seino S,Bryan J.Reconstitution of IKATP:an inward rectifier subunit plus the sulfonylurea recep- tor.Science,1995,270:1166～1170.
  • 2[4]Hani E H,Clement K,Velho G,Vionnet N,Hager J,Philippi A,Dina C,Inoue H,Permutt M A,Basdevant A,North M,De menais F,Guy Grand B,Froguel P.Genetic studies of the sul fonylurea receptor gene locus in NIDDM and in morbid obesity among French Caucasians.Diabetes,1997,46:688～ 694.
  • 3[5]Inoue H,Ferrer J,Welling C M,Elbein S C,Hoffman M,May orga R,Warren P M,Zhang Y,Millns H,Turner R,Province M,Bryan J,Permutt M A,Aguilar B L.Sequence variants in the sulfonylurea receptor (SUR) gene are associated with NIDDM in Caucasians.Diabetes,1996,45:825～831.
  • 4[6]Reis A F,Ye W Z,Laforgue D D,Bellanne C C,Timsit J,Velho G.Association of a variant in exon31 of the sulfonylurea re ceptor (SUR1) gene with type 2 diabetes mellitus in French Caucasians.Hum Genet,2000,107:138～144.
  • 5[7]Hasen T,Echwald S M,Hansen L,Moller A M,Almind K,Clausen J O,Urhammer S A,Inoue H,Ferrer J,Bryan J,Agu ilar B L,Permutt M A,Pedersen O.Decreased tolbutamide stimulated insulin secretion in healthy subjects with sequence variants in the high-affinity sulfonylurea receptor gene.Diabe tes,1998,47:598～605.
  • 6[8]Ohta Y,Tanizawa Y,Inoue H,Hosaka T,Ueda K,Matsutani A,Repunte V P,Yamada M,Kurachi Y,Bryan J,Aguilar B L,Permutt M A,Oka Y.Identification and functional analysis of sulfonylurea receptor 1 variants in Japanese patients with NIDDM.Diabetes,1998,47:476 ～ 481.
  • 7[9]Horvath S,Laird N M.A discordant-sibship test for disequilib rium and linkage:no need for parental data.Am J Hum Genet,1998,63:1886～1897.
  • 8[10]Thomas P M,Cote G J,Wohlk N,Haddad B,Mathew P M,Rabl W,Aguilar B L,Gagel R F,Bryan J.Mutations in the sulfonylurea receptor gene in familial persistent hyperinsulinemic hypoglycemia of infancy.Science,1995,268:426 ～429.
  • 9[11]Boehnke M,Langefeld C D.Genetics association mapping based on discordant sib pairs:the discordant-alleles test.Am J Hum Genet,1998,62:950～961.

共引文献30

同被引文献15

引证文献1

中国临床药理学杂志
2007年 第5期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部