摘要
目的分析腹腔镜联合药物治疗子宫内膜异位症的临床效果。方法回顾性分析我院2007年1月～2011年1月妇科进行腹腔镜手术治疗的92例子宫内膜异位症患者的临床资料。术后分为口服孕三烯酮组、诺雷德治疗组和未应用药物治疗的观察组。三组疗程均为6个月。所有患者均随访2年,比较三组患者术后疗效、复发率、妊娠率及药物不良反应。结果腹腔镜术后孕三烯酮治疗组和诺雷德治疗组的术后疗效、复发率、妊娠率均优于未应用药物治疗的观察组,差异均有统计学意义(P<0.05)。诺雷德治疗组的术后疗效、复发率、妊娠率均优于孕三烯酮治疗组,孕三烯酮组药物不良反应以肝功能影响及高雄激素症状为主,停药1～6个月恢复;诺雷德组表现为低雌激素所致更年期症状,于停药后1～2个月恢复,低雌激素以反向添加疗法预防。结论手术后联合药物治疗子宫内膜异位症可明显降低复发率,提高患者的妊娠发生率.其中术后联合诺雷德治疗子宫内膜异位症的疗效更优于联合孕三烯酮,值得临床推广应用。
Objective To study the curative effect of Celoscope joint drug in the treatment of endometriosis.Methods 92 patients from January 2007 to January 2011 who were diagnosed as endometriosis and treated by celoscope were slected,and patients were randomly divided into three groups,First group added gestrinone after celoscope,Second group added zoladex after celoscope,third group did＇t add drug after celoscope.The course of three groups were six months.All patients were followed up for 2 years.The response rate,recurrence rate,pregnancy rate and drug side effects were compared of three groups.Results The response rate,recurrence rate,pregnancy rate of first ang second group were better than third group,the differences were statistically significant（P0.05）,but Second group were better than first group,the differences were statistically significant（P0.05）.drug side effects of gestrinone group with liver function efect and high androgen symptoms was given priority to stop taking 1～6 months restore,zoladex group showed low estrogen for is the result of menopausal symptoms,stop drug in 1 to 2 months after recovery,low estrogen to reverse add therapy prevention.Conclusion Celoscope joint drug in treatment of endometriosis can reduce the patient＇s recurrence rate and improve the patient＇s pregnancy rate significantly.The curative effect of surgery joint zoladex in treatment of endometriosis is better than gestrinone,and is worthy of clinical application.
出处
《四川医学》
CAS
2013年第7期1025-1027,共3页
Sichuan Medical Journal
