摘要
目的 通过照前给予VitC ,观察其对60 Coγ射线全身照射小鼠的保护作用。方法 将小鼠随机分为正常对照组、照射对照组、VitC实验组 1,2 ,3(照前连续 10d灌胃VitC 15、30、45mg/kg体重 ) ,检测各组小鼠骨髓嗜多染红细胞微核率 ,并作 30d存活率实验。结果 VitC可显著降低 2 .0Gyγ射线诱发小鼠骨髓细胞微核 ,可提高受照小鼠30d存活率 ,延长平均存活时间 ,保护指数达 2 .0 9。结论 VitC对中、高剂量γ射线的损伤具有一定的防护作用。
Objective Protective effects of supplemental vitamin C against 60 Co gamma ray induced wholly damage and genetic damage was investigated in mice.Method Mice were divided into normal control group,irradiation control group and vitamin C experimental group 1,2,3 (which were orally given vitamin C 15,30,45mg/kg.bw for 10 successive days respectively prior to gamma ray irradiation).Micronuclei in the bone marrow polychromatophilic erythrocytes in each group of mice were examined and the 30 day survival rate of mice following whole body 5.0 Gy γ irradiation were also determined.Results Supplemental vitamin C prior to gamma rays irradiation can significantly decrease bone marrow PECMN rate of mice and increase 30 day survival rate and prolong average survival time.The protection factor is 2.09.Conclusion Vitamin C has potent protective effects against gamma irradiation induced damage in mice.In certain dose range,vitamin C can absolutely suppress the gamma rays induced genetic damage in vivo.
出处
《苏州医学院学报》
2000年第9期793-795,共3页
Acta Academiae Medicinae Suzhou
关键词
维生素C
Γ射线
辐射损伤
防护
VitC
γ ray
radiation damage
protective effects
PECMN
