摘要
研究了丝染毒素Ｃ（ＭＭＣ）对人外周，血淋巴细胞姐妹染色单体交换（ＳＣＥ）频率及小鼠骨髓嗜多染红细胞微核率的影响。实验结果表明，随着剂量的增加，ＳＣＥ频率和微核率亦相应增加，并有明显的剂量－反应关系，相关系数分别为ｒ＝０．９７２１及ｒ＝０．９７９３Ｄ．本研究对于ＭＭＣ在临床上的应用具有重要的指导意义。
The effects of mitornycin C (MMC) on the frequencies of micro nucleatederythrocytes in the bone marrow cells of mice and on SCE in human peripheral bloodlymphocytes were studied. The results show that the frequencies of SCE and micronucleated erythrocytes increase along with the Increase of MMC doese, and considerable responserelationships exist, with r = 0.9721 and r = 0.9793. This study will give an important guideto clinical application of MMC.
出处
《南京大学学报（自然科学版）》
CSCD
1994年第4期741-744,共4页
Journal of Nanjing University（Natural Science）
