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乳腺癌患者手术治疗前后Survivin的表达及临床意义 被引量：2

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摘要 目的观察不同人群组织Survivin水平及乳腺癌患者手术治疗前后Survivin水平,探讨其对乳腺癌发生、发展、转移及预后的影响。方法采用免疫组织化学SP法检测160例乳腺癌、70例乳腺良性增生和40例癌旁正常组织Survivin蛋白水平,分析其与临床病理特征的关系。另选取50例乳腺癌患者手术前及手术后组织标本检测Survivin水平进行比较。结果 Survivin在乳腺癌、乳腺良性增生和癌旁正常组织的阳性表达率分别为78.8%、17.1%、0%,与乳腺良性增生和癌旁正常组织比较,乳腺癌患者Survivin蛋白表达明显增加(P<0.05)。Survivin高表达与乳腺癌组织学分级、TNM临床分期、淋巴结转移状况有关(P<0.05),与患者年龄、肿瘤大小无关(P>0.05)。经手术治疗后,乳腺癌患者Survivin表达显著降低,差异有统计学意义(P<0.05)。结论乳腺癌患者存在Survivin的过表达,其对乳腺癌的发生、发展、转移及预后具有重要意义,可作为乳腺癌诊断及判断预后的标志物。
作者 王大勇
机构地区 八宝山煤矿职工医院普通外科
出处 《河北医药》 CAS 2013年第18期2749-2750,共2页 Hebei Medical Journal
关键词 乳腺癌 SURVIVIN 免疫组织化学
分类号 R737.9 [医药卫生—肿瘤]
  • 相关文献

参考文献7

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二级参考文献12

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共引文献11

同被引文献20

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河北医药
2013年 第18期

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