摘要
目的:研究乳腺浸润性导管癌组织中Survivin和Cox-2蛋白的表达情况及与临床病理指标的关系,并探讨两种蛋白间的关系。方法:应用免疫组化SP法检测79例乳腺癌组织、30例癌旁组织中Survivin和Cox-2的表达,并分析各蛋白的表达与临床病理学指标间的关系。结果:79例乳腺癌组织中Survivin和Cox-2的表达率分别为64.56%(51/79)和58.22%(46/79),与癌旁组织相比差异有统计学意义(P<0.05)。Survivin和Cox-2的表达与乳腺癌的组织学分级、临床分期和淋巴结转移有关(P<0.05),而与患者年龄大小、肿瘤大小无关(P>0.05)。在乳腺癌中Survivin和Cox-2表达水平呈正相关(P<0.05)。结论:Survivin和Cox-2高表达与乳腺癌的发生、发展及浸润转移有关,可作为判断乳腺癌生物学行为和预后的重要指标。
Objective：To investigate the expression of Survivin and Cox-2 in invasive ductal carcinoma of breast tissue,and their relationship with clinical pathological features in breast cancer,and their correlation with each other.Methods：The expression of Survivin and Cox-2 was studied in 79 cases of invasive ductal carcinoma of breast tissue and 30 cases of adjacent nontumor tissue by SP immunohistochemistry.Results：The postitive expressions of Survivin and Cox-2 in invasive ductal carcinoma of breast tissue were 64.56％ and 58.22％ respectively.There was a significant different between carcinoma and normal breast tissue（P ＜ 0.05）.The overexpression of Survivin and Cox-2 in breast carcinoma had no relationship with age and the size of tumor,but had relationship with histological classification,clinical staging,and lymph node metastasis （P ＜ 0.05）.Survivin and Cox-2 showed significant correlation with each other.Conclusion：The overexpression of Survivin and Cox-2 may play important role in carcinogenesis and progression of breast carcinoma They may be as the indications of biological behavior and prognosis of breast carcinoma.
出处
《现代肿瘤医学》
CAS
2013年第11期2448-2450,共3页
Journal of Modern Oncology
基金
河北省科学技术研究与发展计划项目(编号:11276103D-32)
