摘要
目的对紫衫类药物应用于老年乳腺癌患者新辅助化疗的疗效和不良反应进行观察和评价。方法选取82例老年乳腺癌患者作为研究对象,随机分为观察组和对照组,观察组50例,对照组32例,观察组应用紫杉醇脂质体单药进行新辅助化疗,对照组应用普通紫杉醇单药进行新辅助化疗,对2组化疗疗效和不良反应进行观察和分析。结果 2组化疗有效率分别为82.0%和81.3%,完全缓解率分别为12.0%和12.5%,2组有效率和完全缓解率比较差异无统计学意义(P>0.05);2组患者治疗前、后的KPS评分变化差异无统计学意义(P>0.05);2组患者中性粒细胞减少、恶心呕吐、腹泻、发热、心悸胸闷、转氨酶异常、总胆红素异常、直接胆红素异常不良反应发生率比较差异有统计学意义(P<0.05)。结论紫杉类药物应用于老年乳腺癌患者新辅助化疗的有效率均较高,其中紫杉醇酯质体在骨髓抑制、胃肠症状和肝功能损伤等方面的不良反应发生率更低,安全性更好,值得临床推广应用。
Objective To observe and evaluate the efficacy and adverse reactions of paclitaxel drugs in the neoadjuvant chemotherapy of the elderly patients with breast cancer. Methods Eighty-two elderly patients with breast cancer were selected as research objects and randomly divided into observation group （n = 52） and control group（ n = 32）. The observation group was treated with paelitaxel liposomes for the neoadjuvant chemotherapy, while the patients in the control group were treated with paclitaxel for neoadjuvant chemotherapy. The curative effects and adverse reactions of the chemotherapy in the two groups were observed and analyzed. Results The chemotherapy efficacy rates of the two groups were 82 % and 81.3 % respectively and the complete remission rates were 12 % and 12.5 % respectively. The differences were not statistically significant （P 〉0. 05）. KPS score did not change after treatment （P〉0.05）. Neutrophil decreased in both groups. The differences in term of nausea, vomiting, diarrhea, fever, palpitation, chest tightness, abnormal aminotransferase, abnormal total bilirubin, abnormal direct bilirubin between the two groups were statistically significant （P 〈 0.05）. Conclusion The efficacy rates of the paclitaxel drugs in neoadjuvant chemotherapy of the elderly patients with breast cancer are higher, in which the incidences of the adverse reactions such as bone marrow suppression, gastrointestinal symptoms and liver function damage of paclitaxel liposome are lower. It has better safety and is worthy of clinical application.
出处
《实用临床医药杂志》
CAS
2013年第15期74-76,共3页
Journal of Clinical Medicine in Practice
关键词
紫杉醇酯质体
紫杉醇
新辅助化疗
老年乳腺癌
疗效观察
paclitaxel liposome
paclitaxel
neoadjuvant chemotherapy
breast cancer inthe elderly population
curative effect observation
