摘要
目的 研究遗传因素在乳腺癌发生中的作用。方法 采用 1∶ 1匹配的病例对照研究方法 ,从我国四个城市的主要医院收集了 1996年 10月～ 1997年 1月间入院的乳腺癌新发病例及其对照计 313对 ,并对其进行家系调查。采用 L ogistic回归分析方法进行乳腺癌危险因素分析。采用L i- Mantel- Gart法进行乳腺癌分离比的估算 ,采用 Falconer回归法进行遗传度估算。结果 乳腺癌家族史是一显著的危险因素 ,且与其它因素之间存在广泛的交互作用。 5 .0 2 %的病例具有乳腺癌家族史。先证家系中一级亲属的乳腺癌累积发病率为 9.99% ,大于二、三级亲属和非血缘亲属。分离比为 0 .0 2 2 7± 0 .0 0 8,遗传度为 35 .6± 5 .8%。结论 遗传因素与乳腺癌发生危险显著相关 ,并可能加强其它危险因素的致癌作用。遗传模式遵循多基因遗传 ,在东西方种族之间 。
Objective To evaluate the contribution of genetic factor to the occurrence of breast cancer. Methods A hospital based case control study was conducted, in which 313 cases of breast cancer collected from the large hospitals of four cities from October 1996 to January 1997 were included, one non cancer patient at similar age was selected to match each case, then pedigree survey was carried out. Logistic regression model and stratification analysis were used for analyzing the data. The methods of Li Mantel Gart and Falconer were used to estimate the segregation ratio and heritability. Results Family history of breast cancer is significantly related to enhanced breast cancer risk, and it widely interacts with other risk factors. 5.02% of the breast cancer patients have family history of breast cancer, which is significantly related to enhanced breast cancer risk only in blood relatives, Accmulative incidence of breast cancer in first drgree relatives of patients is 9.99%, which is larger than that in second, third degree and non blood relatives. Segregtion ratio is 0.021,the heritability among first degree ralatives is 35.6±5.8%.Conclusion Genetic factor is significantly related to enhanced breast cancer risk. The genetic model of breast cancer belongs to polygenetics. Genetic mechanism of Chinese may be different from western women.$$$$
出处
《肿瘤》
CAS
CSCD
北大核心
2000年第4期245-248,共4页
Tumor
