摘要
目的 了解广州市健康人群麻疹、白喉、百日咳和破伤风免疫水平。方法 1 999年在广州市 5个区 (市 )随机抽取 2～ 4岁 ,6～ 8岁 ,1 3～ 1 5岁 ,2 5～ 39岁 4个年龄组健康人群 975份血液标本 ,分别采用酶联免疫 (ELISA)、间接血凝 (IHA)、凝集反应等免疫方法检测麻疹、白喉和破伤风、百日咳的抗体。结果 受检人群中的麻疹、白喉、破伤风平均抗体阳性率分别为 94 8%、89 1 %和 87 1 % ,前者的抗体GMRT为 1 388 2 8,后二者平均抗毒素分别为 0 1 3IU/ml、0 2 0IU/ml;百白咳抗体阳性率高达 97 6 % ,但抗体保护率 ( 44 2 % )及GMRT( 1 86 50 )较低 ;白喉、破伤风和百日咳的抗体水平随年龄增长呈下降趋势。结论 广州市 2～ 39岁人群对麻疹、白喉和破伤风形成较好的群体免疫屏障 ;百日咳抗体水平低 ,需规范接种 ,确保有效免疫 ;为消除白喉流行的隐患和防止新生儿破伤风的发生应加强成人白喉和孕妇破伤风的免疫接种。
Objective To find out the immune level of measles,diphtheria,pertussis and tetanus in healthy population of Guangzhou.Methods A randomized serum sampling was carried out in 975 healthy persons aged 2～4,6～8,13～15 and 25～39 in five districts of Guangzhou in 1999.Antibodies to these diseases were tested by ELISA,IHA and agglutination tests.Result The antibody positive rates of measles,diphtheria and tetanus were 94.8%,89.1% and 87.1% respectively.The antibody GMRT of measles was 1 388.28,and antitoxin of diphtheria and tetanus were 0.13IU/ml and 0.20IU/ml respectively.The antibody positive rate of pertussis reached a higher level(97.6%),but the antibody protective rate(44.2%) and GMRT(186.50) were lower.The antibody levels of diphtheria,pertussis and tetanus decreased with age.Conclusion The higher level of immunity against measles,diphtheria and tetanus have been established in healthy population aged 2～39 of Guangzhou,but the antibody protective rate to pertussis still stayed at low level,so DPT routine immunization coverage should be ensured.DPT immunization in adults and TT in pregnant women should be strengthened to prevent adult diphtheria and neonatal tetanus.
出处
《广东卫生防疫》
2000年第3期4-7,共4页
Guangdong Journal of Health and Epidemic Prevention
关键词
抗体监测
麻疹
白喉
破伤风
百日咳
Antibody detection Measles Diphtheria Pertussis Tetanus
