摘要
目的 利用不同动物模型比较吸入NO对动物急性肺损伤氧合的影响。 方法 应用健康雄性Wistar大鼠和新西兰兔各 14只 ,经右心导管注入油酸制成急性肺损伤模型。 结果 油酸注入大鼠右心后 ,对照组、NO组氧分压由 ( 3 2 2 3± 3 0 2 )mmHg和 ( 3 2 2 3± 2 2 9)mmHg( 1mmHg =0 13 3kPa)降为 ( 10 1 6± 12 9)mmHg和 ( 110 9± 6 1)mmHg ,吸入 40ppmNO 1h后氧分压未有上升趋势。兔急性肺损伤时 ,对照组和NO组氧分压分别由 ( 14 7 2± 11 8)mmHg和 ( 14 3 4± 7 3 )mmHg降为 ( 84 6± 4 8)mmHg和 ( 85 1± 8 6)mmHg ,吸入 2 0 ppm、40 ppmNO上升为 ( 115 1± 10 7)mmHg和 ( 117 7± 11 9)mmHg。 结论 轻度肺损伤时吸入NO可使氧合得到适当改善 ,提高血氧分压。
Objective To Compare the effects of inhaled nitric oxide(iNO) on oxygenation in different model of acute lung injury(ALI).Methods Fourteen rats and fourteen rabbits were included in the experiment.Oleic acid (OA) was administered through a right ventricular catheter and the model of acute lung injury was established.Results In rat model,the injection of OA induced a significant reduction of PaO\-2 from (322\^3±30\^2)mmHg and (322\^3±22\^9)mmHg to (101\^6±12\^9)mmHg and (110\^9±6\^1)mmHg in control and NO group respectively.NO improvements in PaO\-2 were observed during inhalation of 40 ppm NO for 1 h.In rabbit model of ALI,PaO\-2 decreased from (147\^2±11\^8)mmHg and(143\^4±7\^3)mmHg to (84\^6±4\^8)mmHg and (85\^1±8\^69)mmHg in control and NO group.Inhaled 20 ppm and 40 ppm NO significantly increased PaO\-2 to (115\^1±10\^7)mmHg and (117\^7±11\^9)mmHg respectively.Conclusion INO had benefit in amelioration of pulmonary gas change in mild acute lung injury.
出处
《小儿急救医学》
2000年第3期126-127,130,共3页
Pediatric Emergency Medicine
