摘要
目的：探讨吸入一氧化氮（ＮＯ）对缺氧性肺动脉高压患者一氧化氮合酶（ＮＯＳ）和内皮素－ｌ（ＥＴ－ｌ）的影响。方法： １３例肺动脉高压患者行 ＮＯ吸入，分别于吸入 ＮＯ前、吸入 ３０ ｍｉｎ时、停止吸入２ｈ和１２ｈ采肺动脉血，测白细胞中的 ＮＯＳ及血浆中的 ＥＴ－ｌ。结果：吸入ＮＯ前、吸入 ３０ ｍｉｎ时、停止吸入２ｈ和１２ｈ，所测ＮＯＳ值分别为（０．７０±０．２１）ｍｏｌ／ｍｉｎ·ｍｇ－１、（０．７４±０．１４）ｍｏｌ／ｍｉｎ·ｍｇ－１、（０．６４±０．２２）ｍｏｌ／ｍｉｎ·ｍｇ－１和（０．６３±０．１７）ｍｏｌ／ｍｉｎ·ｍｇ－１；所测 ＥＴ－ ｌ为（７８．８９±４６．５９）ｐｍｏｌ／Ｌ、（８８．２７±４５．４１）ｐｍｏｌ／Ｌ、（８０．７６±４２．６６）ｐｍｏｌ／Ｌ和（６１．０７±２９．４４）ｐｍｏｌ／Ｌ；后三者同吸入前比，Ｐ均＞０．０５。结论：缺氧性肺动脉高压患者吸入ＮＯ对机体ＮＯＳ和ＥＴ－ｌ未见明显影响。
AIM: To investigate the effects of nitric oxide (NO) inhalation on nitric oxide synthase (NOS) and endothelin-1 (ET-l) of patients with hypoxic pulmonary hypertension. METHODS: Examined 13 pulmonic blood samples to determine the concentration of NOS in leukocyte and ET - 1 in plasma before NO inhalation, 30 minutes after inhalation, 2 and 12 hours after stopping of inhalation respectiviy. RESULTS: The values taken before inhalation was NOS (0.70 ± 0.21 )mol/min·mg-l, ET-1 (78.89 ± 46.59) Pmol/L; 30 minutes after inhalation (0.74±0.14)mol/min.mg-l, ET - 1 (88 .27 ± 45 .41 )pmol/L; 2 hours after stopping of inhalation NOS (0.64 ± 0.22)mol/min.mg-1, ET - 1 (80.76±42.66)pmol/L; and 12 hours after stopping of inhalation NOS (0. 63± 0. 17)mol/min.mg-1, ET-1(61.07±29.44)pmol/L. NO significant difference was found in the values of NOS and ET- 1 before and after inhalation, P＞ 0. 05. CONCLUSION: The effects of NO inhalation on NOS and ET-l in patients with hypoxic pulmonary hypertension are not significant according to the above investigation.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2000年第4期330-332,共3页
Chinese Journal of Pathophysiology
基金
广东省"五个一"科技兴医工程重点资助
