摘要
本研究采用十二指肠插管注胆汁入闭合肠襻,成功复制出大鼠胰腺炎。结果发现,胰腺炎后6 h肺系数和肺血管外水量显著增高,肺有充血、出血、水肿和肺不张。胰腺病变与肺病变的严重程度呈正相关,12 h胰、肺病变加重,相关更为显著。注胆汁后1 h起血清LPO含量显著升高直至实验结束。肺LPO含量6 h有升高趋势,12 h显著升高,与胰、肺病变程度有平行关系。提示LPO的增高在胰腺炎及其所致肺损伤中具有一定作用。
Rat acute pancreatitis was induced by the injection of dog bile into a closed duodenal loop. It was found that lung index and extravascular lung water were significantly increased 6 h after the induction of pancreatitis. Histological examination revealed pulmonary congestion, edema, and atelecta-sis. There was a strong correlation between pancreatic and pulmonary injury. Increased serum and lung lipid peroxide (LPO) was parallel to the degree of pancreatic and lung injury. The results indicate that increase in LPO may be a result of pancreatitis-induced lung injury.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
1990年第3期240-243,共4页
Academic Journal of Second Military Medical University
关键词
胰腺炎
肺损伤
脂质过氧化物
acute pancreatitis
lung injury
lipid peroxide
rats
