摘要
目的测定正常兔眼球后注射榄香烯后药物在眼内的分布。方法采用气相色谱法测定正常兔眼单次及连续１周球后注射榄香烯后房水、玻璃体、视网膜和脉络膜中β－榄香烯的浓度。结果单次球后注射榄香烯后１ｈ，房水、玻璃体、视网膜和脉络膜中均检测到β－榄香烯。连续１周注射后，仅视网膜和脉络膜中检测到β－榄香烯，浓度与单次注射相比无明显增加。结论正常兔眼球后注射榄香烯可通过血－视网膜屏障进入眼内，连续用药后无明显蓄积作用。
Objective To determine the distribution of β-elemene in normal rabbit eyes after single and repeated retrobulbar injections. Methods Elemene was injected into the retrobulbar space of normal rabbit eyes at a dose of 5mg. Besides single injection, repeated injections were also performed once a d for one week. Aqueous and vitreous were collected. Retinas and choroids were dissected off and reduced to pulp separately. The concentration of p-elemene in these four compartments were measured by gas chromatography. Results β-elemene was found in aqueous,vitreous,retina and choroid 1 h after single retrobulbar injection. The concentrations of β-elemene in these four compartments decreased in the following order: choroid > retina > vitreous > aqueous. After repeated retrobulbar injections for one week, however, β-elemene was found only in retina and choroid,and the concentration of β-elemene in retina was higher than that in choroid. It was also found that the β- elemene concentration in retina after repeated injections was not significantly different in comparison with that after single injection,whereas β-elemene concentration in choroid decreased markedly. Conclusion Elemene can pass the blood-retinal barrier of normal rabbit eye after retrobulbar injection and does not accumulate significantly after one week of repeated injections, implying that elemene has potential value in ophthalmic therapy.
出处
《眼科研究》
CSCD
2000年第4期333-335,共3页
Chinese Ophthalmic Research
