摘要
目的:观察奥曲肽对恶性肠梗阻患者免疫功能的影响方法:60例恶性肠梗阻患者按就诊顺序分为治疗组和对照组各30例对照组给予禁食、胃肠减压、纠正水电解质紊乱和酸碱失衡、肠外营养支持等常规治疗,治疗组在常规治疗基础上加用奥曲肽0.1 mg,ih q8h。疗程10 d。检测治疗前后两组患者细胞免疫指标CD4^+、CD8^+及CD4^+与CD8^+的比值;体液免疫指标IgM、IgA和IgG;免疫调节因子IL-1、IL-6和TNF-α的变化。观察两组患者并发症及不良反应发生情况。结果:治疗10 d后,治疗组CD4^+及CD4^+/CD8^+值;IgM、IgA和IgG值均高于对照组(P<0.05);IL-1、IL-6和TNF-α的浓度均低于对照组(P<0.05);治疗组并发症发生率低于对照组(P<0.05):两组均未发现明显不良反应结论:奥曲肽可改善胃肠道肿瘤所致恶性肠梗阻患者的免疫功能。
Objective：To observe the influence of octreotide on immune function in patients with malignant bowel obstruction.Methods：60 cases ol malignant intestinal obstruction patients according to treatment sequence were randomly divided into the treatment group and controlled group（30 cases in each group）.The controlled group was given some conventional treatments such as fasting,gastrointestinal decompression,correct water and electrolyte disorders and acid-base balance,parenteral nutrition support.The treatment group was given octreotide on the basis of conventional treatment. Their cellular immune indicators CD4~＋,CD8~＋ and CD4~＋ /CD8~＋,humoral immunity indicators IgM,IgA,and IgG and factors of immunomodulatory IL-1,IL-6 and TNK-αwere examined before and after treatment.The complication and adverse reactions were observed among the patients of two groups.Results：After the 10 d treatment,the CD4~＋ and CD4~＋ / CD8~＋ values of the treatment group and IgM,IgA and IgG were higher than those in the controlled group（P 0.05）;IL- 1,IL-6 but TNF-αconcentrations were lower lhan those of the controlled group（P 0.05）.The complication rate of the treatment group was lower than that of the controlled group（P 0.05）;No adverse effects were found in the two groups. Conclusion：Octreotide could improve the immune function of the gastrointestinal cancer causing malignant intestinal obstruction and reduce the incidence ol complications.
出处
《药物流行病学杂志》
CAS
2013年第7期350-352,共3页
Chinese Journal of Pharmacoepidemiology
关键词
奥曲肽
恶性肠梗阻
免疫功能
Octreotide
Malignant bowel obstruction
Immune function
