摘要
目的 :探讨生长抑素联合全肠外营养 (TPN)在不能行手术切除的晚期腹部恶性肿瘤所致肠梗阻治疗中的作用。 方法 :回顾分析近 8个月我科收治的 2 4例晚期腹部肿瘤所致肠梗阻病例 ,观察应用生长抑素联合TPN的治疗结果、生化指标、C 反应蛋白 (CRP)和生活质量评分。 结果 :9例肠梗阻缓解 ,15例梗阻症状得到控制 ;治疗前后血清白蛋白、前白蛋白、纤维连接蛋白、转铁蛋白及血清CRP差异显著 ;治疗后病人生活质量明显改善 ,Karnofsky分值差异显著 ;治疗过程中未发现毒副反应。 结论 :生长抑素联合TPN治疗后能明显改善不能手术切除的恶性肿瘤肠梗阻的不适症状和生活质量 。
Objectives:To investigate the effects of somatostatin combined with total parenteral nutrition (TPN) on unresectable advanced malignant intestinal obstruction. Methods:Twenty four cases of intestinal obstruction due to abdominal advanced malignant tumor were retrospectively analyzed, and we observed the therapeutic results, biochemical measurements, serum concentration of C reactive protein (CRP), life quality score after using somatostatin combined with TPN. Results:Nine cases among 24 completely relieved, 15 cases bowel obstruction partly improved. Serum levels of albumin, prealbumin, fibronectin, transferring increased markedly after therapy while level of C reactive protein decreased maredly. After therapy,life quality,measured with Karnofsky score, improved significantly. There were no obvious side and toxic effects found during therapy. Conclusions:Somatostatin combined with TPN obviously ameliorate malaise symptoms of unresectable advanced malignant intestinal obstruction patients and improve their life quality. Applicated with somatostatin combined with TPN may have an good clinic prospect in advanced malignant intestinal obstruction patients.
出处
《肠外与肠内营养》
CAS
2002年第3期158-160,共3页
Parenteral & Enteral Nutrition
关键词
生长抑素
全肠外营养
肠梗阻
恶性肿瘤
生活质量
Somatostatin, Total parenteral nutrition (TPN)
Intestinal obstruction
Malignant tumor
Life quality
