摘要
特发性膜性肾病(idiopathic membranous nephropathy,IMN)是一种以肾小球基底膜(GBM)上皮细胞下弥漫的免疫复合物沉积,伴GBM弥漫性增厚为病理特点的原发性肾小球疾病。随着足细胞相关致病抗原的陆续发现,目前普遍认为IMN是一种自身免疫性足细胞病,因此,探索足细胞保护途径对于IMN具有十分重要的意义。nephrin是由足细胞合成,同时又具有维持足细胞的正常形态和功能的一种跨膜蛋白,其对于稳定足细胞功能意义重大。目前对于足细胞保护的中西医药物临床上各有利弊,故我们需要寻找是否还存在其他中药能够防止IMN nephrin表达下降、保护足细胞功能。水蛭素临床上长期运用与特发性膜性肾病治疗,其作用机制是多途径的。鉴于IMN蛋白尿、肾脏损害的最根本机制是足细胞损伤,而水蛭素对IMN是否具有稳定nephrin表达、保护足细胞功能却没有更深的研究。进一步深入研究水蛭素是否存在调节nephrin表达,保护足细胞功能,将为水蛭素治疗IMN提供重要的理论和实践依据。
Idiopathic membranous nephropathy（IMN） is a form of diffuse in the glomerular basement membrane（GBM） in epithelial cells of immune complex deposition along GBM diffuse thickening of the pathological features of primary Glomerular Disease.Podocyte-related pathogenic antigens have been found and it is now widely believed that IMN is an autoimmune podocyte disease.Therefore,podocyte protection is of important significance for IMN.Nephrin is produced by podocyte,and it also can a transmembrane protein which can maintain normal shape and function of sufficient cells,which meant a lot for stablizing podocyte function.At current,podocyte protection of traditional Chinese and Western medicine has advantages and disadvantages,so we need to find out if there are other Chinese medicines which can prevent degradation in IMN nephrin expression and protect the podocyte function.Application of hirudin on clinical long-term treatment of idiopathic membranous nephropathy has more ways.Since IMN proteinuria as well as renal impairment is the most fundamental mechanisms of podocyte injury,however whether hirudin has function on stabilizing nephrin expression and protecting the podocyte has not been deeply studied.Further in-depth studies of regulation nephrin expression,protection of podocyte function,and hirudin in treatment of IMN will be given important theoretical and practical basis.
出处
《中华中医药学刊》
CAS
2013年第7期1635-1637,共3页
Chinese Archives of Traditional Chinese Medicine
基金
浙江省医药卫生平台骨干人才计划(2012RCA012)
