摘要
选择我院１９８９年１０月至１９９４年３月经肾穿刺活检检查的３１例原发性肾小球肾炎患者，随机分组，观察了水蛭对肾炎患者血生化指标、尿酶及临床表现的影响。结果表明，水蛭口服９ｇ／ｄ治疗４周后，尿蛋白明显减少，血浆白蛋白明显上升，胆固醇和甘油三酯明显下降（Ｐ＜０．０１或０．０５）；纤维蛋白原和血小板聚集力明显降低（Ｐ均＜０．０１）。但血小板计数、部分凝血活酶时间、凝血酶原时间和出凝血时间无明显变化（Ｐ＞０．０５）；尿Ｎ－乙酰－β－Ｄ－氨基葡萄糖苷酶明显下降（Ｐ＜０．０１）。说明水蛭具有缓解肾小球肾炎蛋白尿和减轻肾实质损伤的作用。
enal biopsy was performed in 3l cases of primary glomerulonephritis and the effect of Hirudo in thesepatients observed.The resuIts revealed that proteinuria decreased significantly,serum albun1in increasedsignificantly and cholesterol,triglyceride reduced significantly 4 weeks after treatment with Hirudo(P<0.01 or P < 0.05);Flbrinogen and platelet aggregation reduced significantly(P<0.01).However,platelet count,partiaI thromboplastin time, bleeding and clotting time did not change (P>0.05);urineNAGase decreased significantly(P<0.0l).It is concluded that Hirudo may decrease proteinuria and alle-viate renal parenchymal damage.
出处
《中华内科杂志》
CAS
CSCD
北大核心
1995年第4期250-252,共3页
Chinese Journal of Internal Medicine
