摘要
目的 观察帕金森病（PD）患者黑质超声（TCS）与脑多巴胺转运体（DAT）代谢脑正电子发射计算机断层显像（PET）是否具有一致性.方法 本研究连续筛选2012年3-10月在天坛医院就诊的拟诊帕金森病患者,进行脑11C-CFT-PET显像和黑质超声检查,应用Kappa一致性分析检验TCS与PET结果的一致性.结果 53例患者完成了TCS与DAT-PET检查,TCS相对于PET检查的灵敏度68.75％,特异度40.00％,阳性预测值91.67％,阴性预测值11.76％,PET与TCS一致性检验Kappa值为0.042,P=0.69,P ＞0.05.结论 对于临床诊断PD的患者,TCS结果阳性对PET阳性有较高预测价值,而TCS结果阴性时,不能排除PD可能,需要行DAT-PET检查进一步明确诊断.
Objective To evaluate the consistency of dopamine transporter （DAT） positron emission tomography （PET） versus transcranial sonography （TCS） of Parkinson disease （PD） patients.Methods A total of 53 clinically diagnosed idopathic PD patients from Beijing Tiantan Hospital underwent 11C-CFT PET and transcranial sonography （TCS）.Asymmetric reduced dopaminergic function was a positive result of PET while unilateral hyperechoic area larger than 0.2 cm2 a positive result of TCS.Kappa test was used to evaluate the consistency of two methods.Results Among them,36 patients （67.92%） were TCS positive while 17 patients （32.08%） TCS negative.There were 48 patients （90.57%） with positive PET whereas PET was negative for 5 patients （9.43%）.TCS and PET were both positive in 33 patients （62.26%） while 2 （3.77%） yielded a double negative result.As compared with the PET results,the sensitivity,specificity,positive predictive value and negative predictive value of TCS were 68.75%,40.00%,91.67% and 11.76% respectively.For Kappa test,Kappa =0.042,P =0.690,P 〉 0.05.It inferred a poor consistency.Conclusion TCS has a high predictive value for PET positive PD patients.For clinically diagnosed PD patients,a positive TCS result highly predicts PD without DAT-PET.However a negative TCS result can not rule out the possibility of PD.DAT-PET needs to be performed for further confirmation.
出处
《中华医学杂志》
CAS
CSCD
北大核心
2013年第25期1944-1947,共4页
National Medical Journal of China
基金
北京市教育委员会科技计划重点项目（KZ201210025028）
北京市科技计划项目.首都临床特色应用研究（Z11110005880000）
北京市卫生系统高层次卫生技术人才培养计划（2011-3-022）
